ANXA6 annexin A6 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: ANXA6provided by VGNC
Official Full Name: annexin A6provided by VGNC
Primary source: VGNC:VGNC:25968
See related: BGD:BT27258; Ensembl:ENSBTAG00000014809
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	7	NC_037334.1 (62357957..62404796, complement)

Chromosome 7 - NC_037334.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037334.1 Chromosome 7 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AnxA6 is a novel receptor that mediates the endocytosis of bovine beta-glucuronidase.
Title: Annexin VI is a mannose-6-phosphate-independent endocytic receptor for bovine β-glucuronidase.
The results showed that alkaline phosphatase activity was significantly increased in matrix vesicles from calcified bovine vascular smooth muscle cells (BVSMCs) compared with noncalcified BVSMCs, as was annexin II and VI content and (45)Ca uptake.
Title: Annexin-mediated matrix vesicle calcification in vascular smooth muscle cells.

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General gene information

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Markers

ANXA6 (e-PCR)
- UniSTS:504874

MARC_23638-23639:1029438382:1 (e-PCR)
- UniSTS:268730

MARC_23640-23641:1041609044:1 (e-PCR)
- UniSTS:268731

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables actin filament binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calcium-dependent phospholipid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cholesterol binding	IEA Inferred from Electronic Annotation more info	PubMed
enables chondroitin sulfate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylserine binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in growth plate cartilage chondrocyte differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitochondrial calcium ion homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of sequestering of calcium ion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neural crest cell migration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in plasma membrane repair	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of muscle contraction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in focal adhesion	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: annexin A6

Names: annexin VI; annexin-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.