GLTP glycolipid transfer protein [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: GLTPprovided by VGNC
Official Full Name: glycolipid transfer proteinprovided by VGNC
Primary source: VGNC:VGNC:50097
See related: BGD:BT19793; Ensembl:ENSBTAG00000002591
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	17	NC_037344.1 (63377029..63399501)

Chromosome 17 - NC_037344.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that GLTP prefers shorter N-linked fully saturated acyl chain glucosylceramides, such as C8, C12, and C16, whereas long C18, C20, and C24-glucosylceramides are all bound more weakly and transported more slowly than their shorter counterparts; also indicate a break-point between C16- and C18-glucosylceramide in the GLTP sensing ability.
Title: Glucosylceramide acyl chain length is sensed by the glycolipid transfer protein.
three different X-ray structures of bovine GLTP at 1.4 angstroms, 1.6 angstroms and 1.8 angstroms resolution, all with a bound fatty acid or glycolipid, were solved.
Title: Structural evidence for adaptive ligand binding of glycolipid transfer protein.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ceramide 1-phosphate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ceramide 1-phosphate transfer activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in ceramide transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: glycolipid transfer protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175799.3 → NP_786993.1 glycolipid transfer protein

See identical proteins and their annotated locations for NP_786993.1

Status: PROVISIONAL

Source sequence(s)

AF209701

UniProtKB/Swiss-Prot

P17403, P68265, Q9MYP3

Conserved Domains (1) summary

pfam08718
Location:22 → 163

GLTP; Glycolipid transfer protein (GLTP)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

Range

63377029..63399501

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024977035.2 → XP_024832803.1 glycolipid transfer protein isoform X2

Conserved Domains (1) summary

pfam08718
Location:22 → 150

GLTP; Glycolipid transfer protein (GLTP)
XM_024977036.2 → XP_024832804.1 glycolipid transfer protein isoform X5

UniProtKB/TrEMBL

Q3MHF5

Related

ENSBTAP00000003355.5, ENSBTAT00000003355.6

Conserved Domains (1) summary

pfam08718
Location:22 → 149

GLTP; Glycolipid transfer protein (GLTP)
XM_059875886.1 → XP_059731869.1 glycolipid transfer protein isoform X1
XM_059875888.1 → XP_059731871.1 glycolipid transfer protein isoform X4
XM_059875887.1 → XP_059731870.1 glycolipid transfer protein isoform X3
XM_059875889.1 → XP_059731872.1 glycolipid transfer protein isoform X6