diras1a DIRAS family, GTP-binding RAS-like 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: diras1aprovided by ZNC
Official Full Name: DIRAS family, GTP-binding RAS-like 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5788
See related: Ensembl:ENSDARG00000028066 AllianceGenome:ZFIN:ZDB-GENE-030131-5788
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: diras1; fi18d11; zgc:55360; wu:fi18d11
Summary: Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within neuron development and trigeminal ganglion development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in nervous system and otic vesicle. Orthologous to human DIRAS1 (DIRAS family GTPase 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (7324819..7341570)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (7314980..7331731)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

diras1a and diras1b enhanced Rac1 activity.
Title: Zebrafish diras1 Promoted Neurite Outgrowth in Neuro-2a Cells and Maintained Trigeminal Ganglion Neurons In Vivo via Rac1-Dependent Pathway.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GDP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within neuron development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trigeminal ganglion development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within trigeminal ganglion development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GTP-binding protein Di-Ras1a

Names: DIRAS family, GTP-binding RAS-like 1; small GTP-binding tumor suppressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199831.1 → NP_956125.1 GTP-binding protein Di-Ras1a

See identical proteins and their annotated locations for NP_956125.1

Status: PROVISIONAL

Source sequence(s)

BC044147

UniProtKB/TrEMBL

Q803Y2

Related

ENSDARP00000038292.2, ENSDART00000031937.4

Conserved Domains (2) summary

smart00173
Location:20 → 171

RAS; Ras subfamily of RAS small GTPases

cl21455
Location:7 → 169

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases