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rrad Ras-related associated with diabetes [ Danio rerio (zebrafish) ]

Gene ID: 327396, updated on 2-Nov-2024

Summary

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Official Symbol
rradprovided by ZNC
Official Full Name
Ras-related associated with diabetesprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5607
See related
Ensembl:ENSDARG00000052011 AllianceGenome:ZFIN:ZDB-GENE-030131-5607
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fi06a10; zgc:63471; wu:fi06a10
Summary
Enables calcium channel regulator activity. Predicted to act upstream of or within negative regulation of high voltage-gated calcium channel activity. Predicted to be active in plasma membrane. Is expressed in cardiovascular system; endocrine system; nervous system; and otic vesicle. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See rrad in Genome Data Viewer
Location:
chromosome: 7
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (44960186..44963154, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (44620963..44623929, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene cadherin 16, KSP-cadherin Neighboring gene uncharacterized LOC108190803 Neighboring gene cadherin 16, KSP-cadherin Neighboring gene cytosolic iron-sulfur assembly component 2B Neighboring gene uncharacterized LOC137490300

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Ancient origins of RGK protein function: modulation of voltage-gated calcium channels preceded the protostome and deuterostome split. Puhl HL 3rd, et al. PLoS One, 2014. PMID 24992013, Free PMC Article
  2. Gene expression analysis of zebrafish retinal ganglion cells during optic nerve regeneration identifies KLF6a and KLF7a as important regulators of axon regeneration. Veldman MB, et al. Dev Biol, 2007 Dec 15. PMID 17949705
  3. Identification and Tissue-Specific Characterization of Novel SHOX-Regulated Genes in Zebrafish Highlights SOX Family Members Among Other Genes. Hoffmann S, et al. Front Genet, 2021. PMID 34122528, Free PMC Article
  4. Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. van der Sar AM, et al. Mol Immunol, 2009 Jul. PMID 19409617
  5. Gene responses in the central nervous system of zebrafish embryos exposed to the neurotoxicant methyl mercury. Ho NY, et al. Environ Sci Technol, 2013 Apr 2. PMID 23458150

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of high voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GTP-binding protein RAD
NP_956092.1
XP_021333082.1
XP_021333083.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199798.1 → NP_956092.1  GTP-binding protein RAD

    See identical proteins and their annotated locations for NP_956092.1

    Status: PROVISIONAL

    Source sequence(s)
    BC055120
    UniProtKB/TrEMBL
    A0A076NBA3, A0A2R8RIM3, Q7SY56
    Related
    ENSDARP00000068225.2, ENSDART00000073735.3
    Conserved Domains (2) summary
    smart00010
    Location:84 → 246
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd04148
    Location:84 → 300
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    44960186..44963154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477408.2 → XP_021333083.1  GTP-binding protein RAD isoform X2

    UniProtKB/TrEMBL
    A0A8M9Q175
    Conserved Domains (1) summary
    cd04148
    Location:52 → 268
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

  2. XM_021477407.2 → XP_021333082.1  GTP-binding protein RAD isoform X1

    UniProtKB/TrEMBL
    A0A8M9PNL4
    Conserved Domains (1) summary
    cd04148
    Location:88 → 304
    RGK; Rem, Rem2, Rad, Gem/Kir (RGK) subfamily of Ras GTPases

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394707.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    231077..234043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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