eif2s3 eukaryotic translation initiation factor 2, subunit 3 gamma [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eif2s3provided by ZNC
Official Full Name: eukaryotic translation initiation factor 2, subunit 3 gammaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5552
See related: Ensembl:ENSDARG00000008292 AllianceGenome:ZFIN:ZDB-GENE-030131-5552
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi03g03; zgc:63805; Su(var)3-9; wu:fi03g03; wu:fi37d04
Summary: Predicted to enable translation initiation factor activity. Predicted to contribute to tRNA binding activity. Predicted to be involved in formation of translation preinitiation complex and positive regulation of translational fidelity. Predicted to act upstream of or within translational initiation. Predicted to be part of eukaryotic translation initiation factor 2 complex. Human ortholog(s) of this gene implicated in MEHMO syndrome. Orthologous to several human genes including EIF2S3 (eukaryotic translation initiation factor 2 subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	24	NC_007135.7 (16983426..17002950)
105	previous assembly	GRCz10 (GCF_000002035.5)	24	NC_007135.6 (16839007..16858531)

Chromosome 24 - NC_007135.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Broadening the phenotypic spectrum and physiological insights related to EIF2S3 variants.
Title: Broadening the phenotypic spectrum and physiological insights related to EIF2S3 variants.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables methionyl-initiator methionine tRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
contributes_to tRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in formation of translation preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of eukaryotic translation initiation factor 2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of eukaryotic translation initiation factor 2 complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 2 subunit 3

Names: eIF-2-gamma; eIF2-gamma; eukaryotic translation initiation factor 2 gamma; eukaryotic translation initiation factor 2 subunit gamma; eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa

NP_997876.2

EC 3.6.5.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212711.3 → NP_997876.2 eukaryotic translation initiation factor 2 subunit 3

Status: VALIDATED

Source sequence(s)

BX469922

UniProtKB/Swiss-Prot

F1QGW6

Related

ENSDARP00000027695.4, ENSDART00000023833.6

Conserved Domains (1) summary

PTZ00327
Location:13 → 466

PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional