U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

f forked [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32718, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
fprovided by FlyBase
Official Full Name
forkedprovided by FlyBase
Primary source
FLYBASE:FBgn0262111
Locus tag
Dmel_CG42864
See related
AllianceGenome:FB:FBgn0262111
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12996; CG42864; CG5424; Dmel\CG42864; X1
Old locus tag
Dmel_CG12996; Dmel_CG5424
Summary
Predicted to enable actin filament binding activity. Involved in several processes, including chaeta morphogenesis; cuticle pattern formation; and imaginal disc-derived appendage morphogenesis. Predicted to be active in cytoplasm. Used to study autosomal recessive nonsyndromic deafness 36. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 36. Orthologous to several human genes including ESPN (espin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
15F4-15F7; 1-57 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (17232942..17280964)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17126975..17174997)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fimbrin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. X-ray induced reversions of the mutant forked-3N in Drosophila melanogaster, a reappraisal. Green MM. Mutat Res, 1977 May. PMID 405581
  2. Drosophila forked locus. McLachlan A. Mol Cell Biol, 1986 Jan. PMID 3023816, Free PMC Article
  3. The Drosophila forked protein induces the formation of actin fiber bundles in vertebrate cells. Grieshaber S, et al. J Cell Sci, 1999 Jul. PMID 10362550
  4. PHENOTYPIC VARIATION AND PSEUDO-ALLELISM AT THE FORKED LOCUS IN Drosophila Melanogaster. Green MM. Proc Natl Acad Sci U S A, 1955 Jun 15. PMID 16589682, Free PMC Article
  5. A FURTHER ANALYSIS OF THE FORKED LOCUS IN DROSOPHILA MELANOGASTER. Green MM. Proc Natl Acad Sci U S A, 1956 Feb. PMID 16589821, Free PMC Article

See all (230) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

mobile_element

  • Loc: 17245916-17246073 mobile_element_type = transposon:G7{}4223

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in antennal morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chaeta morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cuticle pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epidermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing hair organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
forked
Names
CG42864-PB
CG42864-PC
CG42864-PD
CG42864-PF
CG42864-PG
CG42864-PH
CG42864-PI
CG42864-PJ
CG42864-PK
f-PB
f-PC
f-PD
f-PF
f-PG
f-PH
f-PI
f-PJ
f-PK

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    17232942..17280964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201729.1 → NP_001188658.1  forked, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188658.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MSB2
    Conserved Domains (4) summary
    cd00204
    Location:426 → 552
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:470 → 561
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:400 → 452
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:397 → 429
    ANK; ANK repeat [structural motif]

  2. NM_078660.2 → NP_523384.3  forked, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523384.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24341, Q9VX60
    Related
    FBpp0293024, FBtr0304062
    Conserved Domains (4) summary
    cd00204
    Location:72 → 198
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:116 → 207
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:46 → 98
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:43 → 75
    ANK; ANK repeat [structural motif]

  3. NM_001042819.3 → NP_001036284.1  forked, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036284.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHR2
    Conserved Domains (4) summary
    cd00204
    Location:558 → 684
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:602 → 693
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:565 → 618
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:566 → 595
    ANK; ANK repeat [structural motif]

  4. NM_001201731.2 → NP_001188660.1  forked, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188660.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MSB3
    Conserved Domains (4) summary
    cd00204
    Location:401 → 527
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:445 → 536
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:375 → 427
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:372 → 404
    ANK; ANK repeat [structural motif]

  5. NM_176745.1 → NP_788918.1  forked, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788918.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24341, Q9VX60
    Related
    FBpp0293026, FBtr0304064
    Conserved Domains (4) summary
    cd00204
    Location:72 → 198
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:116 → 207
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:46 → 98
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:43 → 75
    ANK; ANK repeat [structural motif]

  6. NM_001201730.1 → NP_001188659.1  forked, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188659.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MSQ2, Q24341
    Conserved Domains (4) summary
    cd00204
    Location:180 → 306
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:224 → 315
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:187 → 240
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:188 → 217
    ANK; ANK repeat [structural motif]

  7. NM_176746.1 → NP_788919.1  forked, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788919.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24341, Q86B49
    Related
    FBpp0293027, FBtr0304065
    Conserved Domains (4) summary
    cd00204
    Location:145 → 271
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:189 → 280
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:152 → 205
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:153 → 182
    ANK; ANK repeat [structural motif]

  8. NM_167563.2 → NP_728070.1  forked, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728070.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24340, Q9VX59
    Related
    FBpp0311215, FBtr0344942

  9. NM_176747.1 → NP_788920.2  forked, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788920.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86B48
    Related
    FBtr0304066
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MSB2 M9MSB2
M9MSB3 M9MSB3
M9MSQ2 M9MSQ2
Q0KHR2 Q0KHR2
Q24339 Q24339
Q24340 Q24340
Q24341 Q24341
Q86B48 Q86B48
Q86B49 Q86B49
Q9VX59 Q9VX59
Q9VX60 Q9VX60

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools