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rhot1a ras homolog family member T1a [ Danio rerio (zebrafish) ]

Gene ID: 327143, updated on 17-Aug-2024

Summary

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Official Symbol
rhot1aprovided by ZNC
Official Full Name
ras homolog family member T1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5354
See related
Ensembl:ENSDARG00000099996 AllianceGenome:ZFIN:ZDB-GENE-030131-5354
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
miro1; rhot1; zgc:55581; zgc:77063; wu:fd14e11; wu:fi14a05
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including mitochondrial outer membrane permeabilization; mitochondrion transport along microtubule; and regulation of mitochondrion organization. Located in mitochondrion. Is expressed in fin bud; head; muscle; and somite. Orthologous to human RHOT1 (ras homolog family member T1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See rhot1a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (26288952..26319758)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (26158084..26188887)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with dual PH domains 2 Neighboring gene uncharacterized LOC103910250 Neighboring gene uncharacterized LOC100331676 Neighboring gene zgc:153240

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of the three zebrafish orthologs of the mitochondrial GTPase Miro/Rhot. Hollister BM, et al. Comp Biochem Physiol B Biochem Mol Biol, 2016 Jan. PMID 26482085
  2. Mitochondria in Embryogenesis: An Organellogenesis Perspective. Arribat Y, et al. Front Cell Dev Biol, 2019. PMID 31824944, Free PMC Article
  3. Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Salas-Vidal E, et al. Genomics, 2005 Jul. PMID 15894457
  4. Xmrk, kras and myc transgenic zebrafish liver cancer models share molecular signatures with subsets of human hepatocellular carcinoma. Zheng W, et al. PLoS One, 2014. PMID 24633177, Free PMC Article
  5. Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes. Garcia-Reyero N, et al. Bull Environ Contam Toxicol, 2016 Jun. PMID 27086301, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial outer membrane permeabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrion transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion transport along microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitochondrial Rho GTPase 1-A
Names
MIRO-1-A
ras homolog gene family member T1-A
ras homolog gene family, member T1
ras homolog gene family, member T1a
NP_997869.1
XP_009297700.1
XP_009297701.1
XP_009297702.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212704.1 → NP_997869.1  mitochondrial Rho GTPase 1-A

    See identical proteins and their annotated locations for NP_997869.1

    Status: PROVISIONAL

    Source sequence(s)
    BC068190
    UniProtKB/Swiss-Prot
    Q6NVC5, Q803L2
    Related
    ENSDARP00000141563.1, ENSDART00000163500.3
    Conserved Domains (6) summary
    smart00174
    Location:7 → 169
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01892
    Location:415 → 593
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:3 → 169
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    COG1100
    Location:418 → 537
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam08355
    Location:341 → 409
    EF_assoc_1; EF hand associated
    pfam08356
    Location:221 → 301
    EF_assoc_2; EF hand associated

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    26288952..26319758
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009299425.3 → XP_009297700.1  mitochondrial Rho GTPase 1-A isoform X1

    UniProtKB/TrEMBL
    A0A8M3B899
    Conserved Domains (6) summary
    smart00174
    Location:7 → 169
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01892
    Location:415 → 582
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:3 → 169
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    COG1100
    Location:418 → 537
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam08355
    Location:341 → 409
    EF_assoc_1; EF hand associated
    pfam08356
    Location:221 → 301
    EF_assoc_2; EF hand associated

  2. XM_009299427.3 → XP_009297702.1  mitochondrial Rho GTPase 1-A isoform X3

    UniProtKB/TrEMBL
    A0A8M3B0X9
    Conserved Domains (6) summary
    smart00174
    Location:7 → 169
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01892
    Location:415 → 582
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:3 → 169
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    COG1100
    Location:418 → 537
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam08355
    Location:341 → 409
    EF_assoc_1; EF hand associated
    pfam08356
    Location:221 → 301
    EF_assoc_2; EF hand associated

  3. XM_009299426.3 → XP_009297701.1  mitochondrial Rho GTPase 1-A isoform X2

    UniProtKB/TrEMBL
    A0A8M3AQV6
    Conserved Domains (6) summary
    smart00174
    Location:7 → 169
    RHO; Rho (Ras homology) subfamily of Ras-like small GTPases
    cd01892
    Location:415 → 582
    Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
    cd01893
    Location:3 → 169
    Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
    COG1100
    Location:418 → 537
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam08355
    Location:341 → 409
    EF_assoc_1; EF hand associated
    pfam08356
    Location:221 → 301
    EF_assoc_2; EF hand associated
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NVC5.1 GenPept UniProtKB/Swiss-Prot:Q6NVC5

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