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dpf2l D4, zinc and double PHD fingers family 2, like [ Danio rerio (zebrafish) ]

Gene ID: 326933, updated on 14-Nov-2024

Summary

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Official Symbol
dpf2lprovided by ZNC
Official Full Name
D4, zinc and double PHD fingers family 2, likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5132
See related
Ensembl:ENSDARG00000037291 AllianceGenome:ZFIN:ZDB-GENE-030131-5132
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
REQ; Dpf2; wu:fe50b03; zgc:110767
Summary
Predicted to enable metal ion binding activity. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 7. Orthologous to human DPF2 (double PHD fingers 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See dpf2l in Genome Data Viewer
Location:
chromosome: 14
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (24267897..24277354, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (23970652..23980109, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene BCL2 interacting protein 1a Neighboring gene cholinergic receptor, muscarinic 1a Neighboring gene uncharacterized LOC107195253 Neighboring gene heterogeneous nuclear ribonucleoprotein A0a Neighboring gene kelch-like family member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Gene loss and evolutionary rates following whole-genome duplication in teleost fishes. Brunet FG, et al. Mol Biol Evol, 2006 Sep. PMID 16809621
  2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC110767

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of nBAF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D4, zinc and double PHD fingers family 2, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212696.2 → NP_997861.2  D4, zinc and double PHD fingers family 2, like

    See identical proteins and their annotated locations for NP_997861.2

    Status: PROVISIONAL

    Source sequence(s)
    BC092130
    UniProtKB/TrEMBL
    A0A0R4IYI6, A0A8N7XJ24, B2GT78, Q58E00
    Related
    ENSDARP00000054242.4, ENSDART00000054243.5
    Conserved Domains (4) summary
    cl02553
    Location:222 → 244
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    cd15530
    Location:341 → 386
    PHD2_d4; PHD finger 2 found in d4 gene family proteins
    cd15691
    Location:284 → 339
    PHD1_DPF2_like; PHD finger 1 found in D4, zinc and double PHD fingers family 2 (DPF2)
    pfam14051
    Location:13 → 79
    Requiem_N; N-terminal domain of DPF2/REQ

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    24267897..24277354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394909.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    236273..245658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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