Atg16 Autophagy-related 16 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Atg16provided by FlyBase
Official Full Name: Autophagy-related 16provided by FlyBase
Primary source: FLYBASE:FBgn0039705
Locus tag: Dmel_CG31033
See related: AllianceGenome:FB:FBgn0039705
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: atg16; ATG16; ATG16L; CG15513; CG18040; CG18683; CG31033; Dmel\CG31033
Summary: Predicted to enable protein-membrane adaptor activity. Involved in several processes, including larval midgut cell programmed cell death; macroautophagy; and regulation of cell differentiation involved in tissue homeostasis. Predicted to be part of Atg12-Atg5-Atg16 complex. Predicted to be active in autophagosome membrane and phagophore assembly site membrane. Is expressed in adult brain; adult pars intercerebralis; adult pars lateralis; and organism. Used to study inflammatory bowel disease 10. Human ortholog(s) of this gene implicated in inflammatory bowel disease 10. Orthologous to several human genes including ATG16L1 (autophagy related 16 like 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: 99C2-99C2; 3-99 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29827281..29835101, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25653003..25660823, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Atg16 delays the alcohol-induced sedation response via regulation of Corazonin neuropeptide production in Drosophila.
Title: Loss of Atg16 delays the alcohol-induced sedation response via regulation of Corazonin neuropeptide production in Drosophila.
loss of Atg16 or its binding partner Rab19 impairs Slit production, which normally inhibits enteroendocrine cell generation by activating Robo signaling in stem cells.
Title: Drosophila Atg16 promotes enteroendocrine cell differentiation via regulation of intestinal Slit/Robo signaling.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein-membrane adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in enteroendocrine cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval midgut cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in macroautophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell differentiation involved in tissue homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell differentiation involved in tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reticulophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Atg12-Atg5-Atg16 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Atg12-Atg5-Atg16 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in autophagosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in phagophore assembly site membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Autophagy-related 16

Names: Atg16-PA; Atg16-PB; Atg16-PC; Atg16-PF; Autophagy-specific gene 16; CG31033-PA; CG31033-PB; CG31033-PC; CG31033-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

29827281..29835101 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170434.4 → NP_733313.2 Autophagy-related 16, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733313.2

Status: REVIEWED

UniProtKB/TrEMBL

Q86BR6

Related

FBpp0084894

Conserved Domains (5) summary

COG2319
Location:333 → 604

WD40; WD40 repeat [General function prediction only]

cd00200
Location:314 → 597

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08614
Location:11 → 197

ATG16; Autophagy protein 16 (ATG16)

sd00039
Location:323 → 360

7WD40; WD40 repeat [structural motif]

cl00143
Location:120 → 221

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
NM_001144652.2 → NP_001138124.2 Autophagy-related 16, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138124.2

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0R7

Conserved Domains (5) summary

COG2319
Location:341 → 612

WD40; WD40 repeat [General function prediction only]

cd00200
Location:322 → 605

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08614
Location:11 → 197

ATG16; Autophagy protein 16 (ATG16)

sd00039
Location:331 → 368

7WD40; WD40 repeat [structural motif]

cl00143
Location:120 → 229

SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
NM_170432.3 → NP_733311.2 Autophagy-related 16, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733311.2

Status: REVIEWED

UniProtKB/TrEMBL

H0RNK4, Q95TJ1

Related

FBpp0084895

Conserved Domains (3) summary

COG2319
Location:148 → 419

WD40; WD40 repeat [General function prediction only]

cd00200
Location:129 → 412

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:138 → 175

7WD40; WD40 repeat [structural motif]
NM_170433.3 → NP_733312.2 Autophagy-related 16, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733312.2

Status: REVIEWED

UniProtKB/TrEMBL

C6TP88, Q9VAF9, Q9VAG0

Related

FBpp0084896

Conserved Domains (3) summary

COG2319
Location:174 → 445

WD40; WD40 repeat [General function prediction only]

cd00200
Location:155 → 438

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:164 → 201

7WD40; WD40 repeat [structural motif]