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CG9981 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32609, updated on 2-Nov-2024

Summary

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Official Symbol
CG9981provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030746
Locus tag
Dmel_CG9981
See related
AllianceGenome:FB:FBgn0030746
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
DmCG9981; Dmel\CG9981
Summary
Predicted to enable flippase activity. Predicted to be involved in phospholipid translocation. Predicted to be located in membrane. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in endoplasmic reticulum and plasma membrane. Human ortholog(s) of this gene implicated in X-linked congenital hemolytic anemia; autosomal dominant nonsyndromic deafness; and hypomyelinating leukodystrophy 24. Orthologous to human ATP11A (ATPase phospholipid transporting 11A); ATP11B (ATPase phospholipid transporting 11B (putative)); and ATP11C (ATPase phospholipid transporting 11C). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG9981 in Genome Data Viewer
Location:
14C3-14C4; 1-53 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16399782..16405122, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16293815..16299155, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene TH1 Neighboring gene meiotic 41 Neighboring gene uncharacterized protein Neighboring gene TNF-receptor-associated factor-like Neighboring gene Annexin B11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functions of phospholipid flippases. Tanaka K, et al. J Biochem, 2011 Feb. PMID 21134888
  2. Extreme deformability of insect cell membranes is governed by phospholipid scrambling. Shiomi A, et al. Cell Rep, 2021 Jun 8. PMID 34107250
  3. P-type ATPases in Caenorhabditis and Drosophila: implications for evolution of the P-type ATPase subunit families with special reference to the Na,K-ATPase and H,K-ATPase subgroup. Okamura H, et al. J Membr Biol, 2003 Jan 1. PMID 12532273
  4. Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila. Ma Z, et al. Genetics, 2012 Apr. PMID 22234859, Free PMC Article
  5. Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. Huang J, et al. PNAS Nexus, 2023 Dec. PMID 38059264, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATPase-coupled intramembrane lipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled intramembrane lipid transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables flippase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid translocation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
part_of phospholipid-translocating ATPase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG9981-PA
CG9981-PB
CG9981-PC
NP_001259610.1
NP_001259611.1
NP_573124.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16399782..16405122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272682.2 → NP_001259611.1  uncharacterized protein Dmel_CG9981, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259611.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXG7
    Conserved Domains (6) summary
    TIGR01652
    Location:28 → 1051
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:84 → 189
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:489 → 568
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:20 → 66
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:804 → 1050
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:758 → 807
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  2. NM_001272681.1 → NP_001259610.1  uncharacterized protein Dmel_CG9981, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259610.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXG7
    Conserved Domains (6) summary
    TIGR01652
    Location:28 → 1051
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:84 → 189
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:489 → 568
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:20 → 66
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:804 → 1050
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:758 → 807
    HAD_like; Haloacid Dehalogenase-like Hydrolases

  3. NM_132896.2 → NP_573124.1  uncharacterized protein Dmel_CG9981, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573124.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXG7
    Related
    FBpp0074079
    Conserved Domains (6) summary
    TIGR01652
    Location:28 → 1051
    ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
    pfam00122
    Location:84 → 189
    E1-E2_ATPase; E1-E2 ATPase
    pfam13246
    Location:489 → 568
    Cation_ATPase; Cation transport ATPase (P-type)
    pfam16209
    Location:20 → 66
    PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
    pfam16212
    Location:804 → 1050
    PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
    cl21460
    Location:758 → 807
    HAD_like; Haloacid Dehalogenase-like Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXG7 Q9VXG7

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