mhc2d4b major histocompatibility complex class II d4b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mhc2d4bprovided by ZNC
Official Full Name: major histocompatibility complex class II d4bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-4747
See related: Ensembl:ENSDARG00000101030 AllianceGenome:ZFIN:ZDB-GENE-030131-4747
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: D4B; wu:fd58b11; si:ch73-158p21.3
Summary: Predicted to enable MHC class II protein complex binding activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to act upstream of or within antigen processing and presentation and immune response. Predicted to be located in membrane. Predicted to be part of MHC class II protein complex. Orthologous to human HLA-DQB2 (major histocompatibility complex, class II, DQ beta 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (76362876..76370686, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (74783079..74789606, complement)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables MHC class II protein complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide antigen binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antigen processing and presentation	IEA Inferred from Electronic Annotation more info
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
involved_in peptide antigen assembly with MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MHC class II protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MHC class II protein complex	IEA Inferred from Electronic Annotation more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

Preferred Names: H-2 class II histocompatibility antigen, E-S beta chain; uncharacterized protein LOC326022

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The following sections contain reference sequences that belong to a specific genome build. Explain