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eas easily shocked [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32585, updated on 2-Nov-2024

Summary

Official Symbol
easprovided by FlyBase
Official Full Name
easily shockedprovided by FlyBase
Primary source
FLYBASE:FBgn0000536
Locus tag
Dmel_CG3525
See related
AllianceGenome:FB:FBgn0000536
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ala; CG3525; Dmel\CG3525; EP770; EtnK; PC80; RE10142; RH11
Summary
Enables ethanolamine kinase activity. Involved in several processes, including mechanosensory behavior; nervous system development; and phosphatidylethanolamine metabolic process. Predicted to be active in cytoplasm. Used to study epilepsy and heart conduction disease. Orthologous to several human genes including ETNK1 (ethanolamine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See eas in Genome Data Viewer
Location:
14B7-14B7; 1-53 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16278328..16285618)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16172361..16179651)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene katanin 80 Neighboring gene peroxisomal Multifunctional enzyme type 2 Neighboring gene Proteasome alpha4 subunit Neighboring gene uncharacterized protein Neighboring gene Ubiquinol-cytochrome c reductase 14 kDa subunit Neighboring gene cabeza

Genomic regions, transcripts, and products

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables choline kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables ethanolamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ethanolamine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
easily shocked
Names
CG3525-PA
CG3525-PB
CG3525-PC
CG3525-PF
CG3525-PG
CG3525-PH
CG3525-PI
CG3525-PJ
alpha lobes absent
alpha-lobe absent
eas-PA
eas-PB
eas-PC
eas-PF
eas-PG
eas-PH
eas-PI
eas-PJ
easily-shocked
ethanolamine kinase
NP_001245706.1
NP_001245707.1
NP_001285319.1
NP_523364.2
NP_727941.2
NP_727942.1
NP_727943.1
NP_788914.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16278328..16285618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258777.1NP_001245706.1  easily shocked, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245706.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JFQ7
  2. NM_001298390.1NP_001285319.1  easily shocked, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285319.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JFQ7
  3. NM_167489.2NP_727941.2  easily shocked, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727941.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C8VV66, M9NEJ9, M9NGH8, P54352, Q1RL01, Q540Y9, Q86B51, Q8IR20, Q9VXI7
    Conserved Domains (1) summary
    cd05157
    Location:126478
    ETNK_euk; Euykaryotic Ethanolamine kinase
  4. NM_001258778.2NP_001245707.1  easily shocked, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245707.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54352
  5. NM_167490.3NP_727942.1  easily shocked, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727942.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C8VV66, M9NEJ9, M9NGH8, P54352, Q1RL01, Q540Y9, Q86B51, Q8IR20, Q9VXI7
    Related
    FBpp0073990
    Conserved Domains (1) summary
    cd05157
    Location:126478
    ETNK_euk; Euykaryotic Ethanolamine kinase
  6. NM_176741.3NP_788914.2  easily shocked, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788914.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C8VV66, M9NEJ9, M9NGH8, P54352, Q1RL01, Q540Y9, Q86B51, Q8IR20, Q9VXI7
    Conserved Domains (1) summary
    cd05157
    Location:126478
    ETNK_euk; Euykaryotic Ethanolamine kinase
  7. NM_078640.4NP_523364.2  easily shocked, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523364.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C8VV66, M9NEJ9, M9NGH8, P54352, Q1RL01, Q540Y9, Q86B51, Q8IR20, Q9VXI7
    Related
    FBpp0073991
    Conserved Domains (1) summary
    cd05157
    Location:126478
    ETNK_euk; Euykaryotic Ethanolamine kinase
  8. NM_167491.2NP_727943.1  easily shocked, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727943.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C8VV66, M9NEJ9, M9NGH8, P54352, Q1RL01, Q540Y9, Q86B51, Q8IR20, Q9VXI7
    Related
    FBpp0073993
    Conserved Domains (1) summary
    cd05157
    Location:126478
    ETNK_euk; Euykaryotic Ethanolamine kinase