U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

vap vacuolar peduncle [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32569, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
vapprovided by FlyBase
Official Full Name
vacuolar peduncleprovided by FlyBase
Primary source
FLYBASE:FBgn0003969
Locus tag
Dmel_CG9209
See related
AllianceGenome:FB:FBgn0003969
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9209; D-RasGAP; Dmel\CG9209; FBpp0073946; p120 RasGAP; p120RasGAP; RAS-GAP; rasGap; RasGap; RasGAP; RasGAP/Vap
Summary
Enables GTPase activator activity; phosphotyrosine residue binding activity; and signaling receptor binding activity. Involved in several processes, including behavioral response to ethanol; mushroom body development; and negative regulation of signal transduction. Located in cytosol. Is expressed in several structures, including embryonic/larval nervous system; hindgut anlage; spermatozoon; trunk ectoderm; and ventral nerve cord primordium. Used to study alcohol use disorder and neurodegenerative disease. Human ortholog(s) of this gene implicated in arteriovenous malformation and basal cell carcinoma. Orthologous to human RASA1 (RAS p21 protein activator 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See vap in Genome Data Viewer
Location:
14A5-14A6; 1-52 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15999951..16005812, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15893984..15899845, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene extradenticle Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mucin 14A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Capns1, a new binding partner of RasGAP-SH3 domain in K-Ras(V12) oncogenic cells: modulation of cell survival and migration. Pamonsinlapatham P, et al. Cell Signal, 2008 Nov. PMID 18761085
  2. Mutants of brain structure and function: what is the significance of the mushroom bodies for behavior? Heisenberg M. Basic Life Sci, 1980. PMID 6779802
  3. Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway. Cleghon V, et al. Mol Cell, 1998 Dec. PMID 9885560
  4. p120 Ras GTPase-activating protein associates with fibroblast growth factor receptors in Drosophila. Woodcock SA, et al. Biochem J, 2004 Jun 15. PMID 15030317, Free PMC Article
  5. Identification of Aurora kinases as RasGAP Src homology 3 domain-binding proteins. Gigoux V, et al. J Biol Chem, 2002 Jun 28. PMID 11976319

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fibroblast growth factor receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphotyrosine residue binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables torso binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of torso signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
vacuolar peduncle
Names
CG9209-PA
CG9209-PB
CG9209-PC
CG9209-PD
CG9209-PE
CG9209-PF
Ras GTPase-activating protein
p120 Ras GTPase-activating protein
vacuolar peduncule
vacuolar pedunculi
vap-PA
vap-PB
vap-PC
vap-PD
vap-PE
vap-PF

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15999951..16005812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298385.1 → NP_001285314.1  vacuolar peduncle, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285314.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR23
    Conserved Domains (6) summary
    cd08400
    Location:499 → 622
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:64 → 166
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:252 → 326
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:183 → 241
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd13260
    Location:379 → 484
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
    cl02569
    Location:620 → 954
    RasGAP; Ras GTPase Activating Domain

  2. NM_078637.3 → NP_523361.1  vacuolar peduncle, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523361.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR23
    Related
    FBpp0073945
    Conserved Domains (6) summary
    cd08400
    Location:499 → 622
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:64 → 166
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:252 → 326
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:183 → 241
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd13260
    Location:379 → 484
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
    cl02569
    Location:620 → 954
    RasGAP; Ras GTPase Activating Domain

  3. NM_167480.2 → NP_727925.1  vacuolar peduncle, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727925.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR23
    Related
    FBpp0073946
    Conserved Domains (6) summary
    cd08400
    Location:499 → 622
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:64 → 166
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:252 → 326
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:183 → 241
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd13260
    Location:379 → 484
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
    cl02569
    Location:620 → 954
    RasGAP; Ras GTPase Activating Domain

  4. NM_206759.2 → NP_996482.1  vacuolar peduncle, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996482.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR23
    Conserved Domains (6) summary
    cd08400
    Location:499 → 622
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:64 → 166
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:252 → 326
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:183 → 241
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd13260
    Location:379 → 484
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
    cl02569
    Location:620 → 954
    RasGAP; Ras GTPase Activating Domain

  5. NM_167481.3 → NP_727926.2  vacuolar peduncle, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727926.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR23
    Related
    FBpp0089147
    Conserved Domains (6) summary
    cd08400
    Location:499 → 622
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:64 → 166
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:252 → 326
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:183 → 241
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd13260
    Location:379 → 484
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
    cl02569
    Location:620 → 954
    RasGAP; Ras GTPase Activating Domain

  6. NM_001298386.1 → NP_001285315.1  vacuolar peduncle, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285315.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IR23
    Conserved Domains (6) summary
    cd08400
    Location:499 → 622
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:64 → 166
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:252 → 326
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:183 → 241
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd13260
    Location:379 → 484
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
    cl02569
    Location:620 → 954
    RasGAP; Ras GTPase Activating Domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IR23 Q8IR23
Q8T9B1 Q8T9B1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous