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irf2a interferon regulatory factor 2a [ Danio rerio (zebrafish) ]

Gene ID: 325410, updated on 2-Nov-2024

Summary

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Official Symbol
irf2aprovided by ZNC
Official Full Name
interferon regulatory factor 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4135
See related
Ensembl:ENSDARG00000007387 AllianceGenome:ZFIN:ZDB-GENE-030131-4135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:76951; wu:fc74h04
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in immune system process and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human IRF2 (interferon regulatory factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See irf2a in Genome Data Viewer
Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (39865650..39880260)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (39141746..39162187)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene teneurin transmembrane protein 3 Neighboring gene uncharacterized LOC137495619 Neighboring gene dCMP deaminase Neighboring gene transmembrane protein 134 Neighboring gene storkhead box 2a Neighboring gene superoxide dismutase 3, extracellular b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition. Sapp V, et al. Hepatology, 2014 Nov. PMID 25043405
  2. IRF2 Cooperates with Phosphoprotein of Spring Viremia of Carp Virus to Suppress Antiviral Response in Zebrafish. Huang W, et al. J Virol, 2022 Nov 23. PMID 36314827, Free PMC Article
  3. Global characterization of interferon regulatory factor (IRF) genes in vertebrates: glimpse of the diversification in evolution. Huang B, et al. BMC Immunol, 2010 May 5. PMID 20444275, Free PMC Article
  4. Rutin protects hemorrhagic stroke development via supressing oxidative stress and inflammatory events in a zebrafish model. Rana AK, et al. Eur J Pharmacol, 2022 Jun 15. PMID 35469838
  5. Zebrafish embryo model of Bartonella henselae infection. Lima A, et al. Zebrafish, 2014 Oct. PMID 25026365, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
interferon regulatory factor 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001326712.1 → NP_001313641.1  interferon regulatory factor 2a isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    CR847546, CU929244
    UniProtKB/TrEMBL
    A0A8M1P3M0, F1Q8A2
    Related
    ENSDARP00000115520.2, ENSDART00000131954.4
    Conserved Domains (1) summary
    pfam00605
    Location:7 → 112
    IRF; Interferon regulatory factor transcription factor

  2. NM_207054.2 → NP_996937.2  interferon regulatory factor 2a isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    CR847546, CU929244
    UniProtKB/TrEMBL
    A0A8M1PF24, B8JIT5
    Related
    ENSDARP00000107609.1, ENSDART00000130270.2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    39865650..39880260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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