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sd scalloped [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32536, updated on 2-Nov-2024

Summary

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Official Symbol
sdprovided by FlyBase
Official Full Name
scallopedprovided by FlyBase
Primary source
FLYBASE:FBgn0003345
Locus tag
Dmel_CG8544
See related
AllianceGenome:FB:FBgn0003345
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-2.14; CG8544; clone 2.14; Dmel\CG8544; DROEXO; DROEXO2; EP(X)1088; EP1088; l(1)G0239; l(1)G0262; l(1)G0309; l(1)G0315; l(1)G0483; l(1)HF394; l(1)III; Sd; SD; sp; TEAD
Summary
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coregulator binding activity. Involved in several processes, including imaginal disc-derived appendage morphogenesis; negative regulation of neuroblast proliferation; and regulation of DNA-templated transcription. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including ganglia; imaginal disc; myoblast; sense organ; and somatic muscle cell. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Orthologous to several human genes including TEAD3 (TEA domain transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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Location:
13F1-13F5; 1-52 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15804370..15827682)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15698403..15721714)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein LE Neighboring gene long non-coding RNA:CR44384 Neighboring gene uncharacterized protein Neighboring gene Clathrin heavy chain Neighboring gene long non-coding RNA:CR32582

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The scalloped gene encodes a novel, evolutionarily conserved transcription factor required for sensory organ differentiation in Drosophila. Campbell S, et al. Genes Dev, 1992 Mar. PMID 1547938
  2. Cloning and characterization of the scalloped region of Drosophila melanogaster. Campbell SD, et al. Genetics, 1991 Feb. PMID 1706292, Free PMC Article
  3. Scalloped a member of the Hippo tumor suppressor pathway controls mushroom body size in Drosophila brain by non-canonical regulation of neuroblast proliferation. Rohith BN, et al. Dev Biol, 2017 Dec 15. PMID 29080790
  4. Developmental Deformity Due to scalloped Non-Function in Drosophila Brain Leads to Cognitive Impairment. Rohith BN, et al. Dev Neurobiol, 2019 Mar. PMID 30676700
  5. Causes and consequences of genetic background effects illuminated by integrative genomic analysis. Chandler CH, et al. Genetics, 2014 Apr. PMID 24504186, Free PMC Article

See all (408) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications.
    Title: Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications.
  2. Two central players in controlling Hippo-dependent gene expression are the TEAD transcription factor Scalloped (Sd) and its transcriptional co-activator Yorkie (Yki).
    Title: Opposing transcriptional and post-transcriptional roles for Scalloped in binary Hippo-dependent neural fate decisions.
  3. In this study, the authors identify Nerfin-1 as a transcriptional repressor that antagonizes the activity of the Sd-Yki complex by binding to the TEA DNA-binding domain of Sd. Consistent with its biochemical function, ectopic expression of Nerfin-1 results in tissue undergrowth in an Sd-dependent manner.
    Title: Nerfin-1 represses transcriptional output of Hippo signaling in cell competition.
  4. Scalloped (Sd) and Nervous fingers-1 (Nerfin-1) transcription factors physically and functionally interact to maintain medulla neuron fate in the Drosophila melanogaster central nervous system.
    Title: The Scalloped and Nerfin-1 Transcription Factors Cooperate to Maintain Neuronal Cell Fate.
  5. These findings suggest that spatiotemporal expression of transcription factor Sd induces differential growth regulation by Yki during wing disc development, highlighting coordination between Yki and CycE to control growth and maintain homeostasis.
    Title: Differential Regulation of Cyclin E by Yorkie-Scalloped Signaling in Organ Development.
  6. DNA-binding transcription factor Scalloped mediates both Yorkie overexpression and loss-of-function phenotypes yet is itself dispensable for normal eye development
    Title: Validating upstream regulators of Yorkie activity in Hippo signaling through scalloped-based genetic epistasis.
  7. found that human E2F1 competes with YAP for TEAD1 binding, affecting YAP activity, indicating that this mode of cross-regulation is conserved
    Title: A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size.
  8. Data show that Yorkie (Yki) and Scalloped (Sd) are required for epidermal wound closure in the larval epidermis.
    Title: Yorkie regulates epidermal wound healing in Drosophila larvae independently of cell proliferation and apoptosis.
  9. Vestigial protein phosphorylation of serine 215 occurs in the nucleus and requires the presence of Scalloped.
    Title: The activity of the Drosophila Vestigial protein is modified by Scalloped-dependent phosphorylation.
  10. Data indicate that the TEAD family transcription factor Scalloped (Scalloped) regulates PDGF/VEGFR receptor (Pvr) expression.
    Title: The TEAD family transcription factor Scalloped regulates blood progenitor maintenance and proliferation in Drosophila through PDGF/VEGFR receptor (Pvr) signaling.
Submit: New GeneRIF Correction See all GeneRIFs (28)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of neuroblast proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of heart morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stem cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in wing disc development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
scalloped
Names
CG8544-PA
CG8544-PB
CG8544-PC
CG8544-PD
CG8544-PE
CG8544-PF
CG8544-PG
CG8544-PH
CG8544-PI
CG8544-PJ
CG8544-PK
CG8544-PL
CG8544-PM
CG8544-PN
CG8544-PO
CG8544-PP
CG8544-PQ
CG8544-PR
CG8544-PS
CG8544-PT
CG8544-PU
CG8544-PV
sd-PA
sd-PB
sd-PC
sd-PD
sd-PE
sd-PF
sd-PG
sd-PH
sd-PI
sd-PJ
sd-PK
sd-PL
sd-PM
sd-PN
sd-PO
sd-PP
sd-PQ
sd-PR
sd-PS
sd-PT
sd-PU
sd-PV
spatula

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15804370..15827682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316637.1 → NP_001303566.1  scalloped, isoform U [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUY5, Q058U0
    Conserved Domains (2) summary
    smart00426
    Location:63 → 130
    TEA; TEA domain
    pfam17725
    Location:199 → 407
    YBD; YAP binding domain

  2. NM_001258767.2 → NP_001245696.1  scalloped, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245696.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUY5, Q058U0
    Conserved Domains (2) summary
    smart00426
    Location:63 → 130
    TEA; TEA domain
    pfam17725
    Location:199 → 407
    YBD; YAP binding domain

  3. NM_001258772.2 → NP_001245701.1  scalloped, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245701.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUY5, Q058U0
    Conserved Domains (2) summary
    smart00426
    Location:63 → 130
    TEA; TEA domain
    pfam17725
    Location:199 → 407
    YBD; YAP binding domain

  4. NM_001258773.2 → NP_001245702.1  scalloped, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245702.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUY5, Q058U0
    Conserved Domains (2) summary
    smart00426
    Location:63 → 130
    TEA; TEA domain
    pfam17725
    Location:199 → 407
    YBD; YAP binding domain

  5. NM_001103519.3 → NP_001096989.1  scalloped, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096989.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JUY5, Q058U0
    Conserved Domains (2) summary
    smart00426
    Location:63 → 130
    TEA; TEA domain
    pfam17725
    Location:199 → 407
    YBD; YAP binding domain

  6. NM_001258768.1 → NP_001245697.1  scalloped, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245697.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30052, Q9VXN7
    UniProtKB/TrEMBL
    A8JUY9, F3YDC4
    Conserved Domains (2) summary
    smart00426
    Location:88 → 155
    TEA; TEA domain
    pfam17725
    Location:229 → 437
    YBD; YAP binding domain

  7. NM_001298370.1 → NP_001285299.1  scalloped, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285299.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F3YDC4, X2JFL9
    Conserved Domains (2) summary
    smart00426
    Location:23 → 90
    TEA; TEA domain
    pfam17725
    Location:164 → 372
    YBD; YAP binding domain

  8. NM_001382196.1 → NP_001368984.1  scalloped, isoform V [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6H2EE76
    Conserved Domains (2) summary
    smart00426
    Location:88 → 155
    TEA; TEA domain
    pfam17725
    Location:224 → 432
    YBD; YAP binding domain

  9. NM_001258770.3 → NP_001245699.1  scalloped, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245699.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJ99, Q058U0
    Conserved Domains (2) summary
    smart00426
    Location:88 → 155
    TEA; TEA domain
    pfam17725
    Location:224 → 432
    YBD; YAP binding domain

  10. NM_001258771.3 → NP_001245700.1  scalloped, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245700.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q058U0, Q8IR25
    Conserved Domains (1) summary
    smart00426
    Location:23 → 90
    TEA; TEA domain

  11. NM_078614.5 → NP_511169.1  scalloped, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511169.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30052, Q9VXN7
    UniProtKB/TrEMBL
    A8JUY9, F3YDC4
    Related
    FBpp0073914
    Conserved Domains (2) summary
    smart00426
    Location:88 → 155
    TEA; TEA domain
    pfam17725
    Location:229 → 437
    YBD; YAP binding domain

  12. NM_001103520.3 → NP_001096990.1  scalloped, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096990.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30052, Q9VXN7
    UniProtKB/TrEMBL
    A8JUY9, F3YDC4
    Conserved Domains (2) summary
    smart00426
    Location:88 → 155
    TEA; TEA domain
    pfam17725
    Location:229 → 437
    YBD; YAP binding domain

  13. NM_001169290.2 → NP_001162761.1  scalloped, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162761.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJ99, Q058U0
    Conserved Domains (2) summary
    smart00426
    Location:88 → 155
    TEA; TEA domain
    pfam17725
    Location:224 → 432
    YBD; YAP binding domain

  14. NM_001103522.3 → NP_001096992.1  scalloped, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096992.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30052, Q9VXN7
    UniProtKB/TrEMBL
    A8JUY9, F3YDC4
    Conserved Domains (2) summary
    smart00426
    Location:88 → 155
    TEA; TEA domain
    pfam17725
    Location:229 → 437
    YBD; YAP binding domain

  15. NM_167465.3 → NP_727900.1  scalloped, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727900.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q058U0, Q8IR25
    Related
    FBpp0073915
    Conserved Domains (1) summary
    smart00426
    Location:23 → 90
    TEA; TEA domain

  16. NM_001169291.2 → NP_001162762.1  scalloped, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162762.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJ99, Q058U0
    Conserved Domains (2) summary
    smart00426
    Location:88 → 155
    TEA; TEA domain
    pfam17725
    Location:224 → 432
    YBD; YAP binding domain

  17. NM_001103521.3 → NP_001096991.1  scalloped, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096991.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30052, Q9VXN7
    UniProtKB/TrEMBL
    A8JUY9, F3YDC4
    Conserved Domains (2) summary
    smart00426
    Location:88 → 155
    TEA; TEA domain
    pfam17725
    Location:229 → 437
    YBD; YAP binding domain

  18. NM_001272654.2 → NP_001259583.1  scalloped, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259583.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30052, Q9VXN7
    UniProtKB/TrEMBL
    A8JUY9, F3YDC4
    Conserved Domains (2) summary
    smart00426
    Location:88 → 155
    TEA; TEA domain
    pfam17725
    Location:229 → 437
    YBD; YAP binding domain

  19. NM_001272653.2 → NP_001259582.1  scalloped, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259582.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30052, Q9VXN7
    UniProtKB/TrEMBL
    A8JUY9, F3YDC4
    Conserved Domains (2) summary
    smart00426
    Location:88 → 155
    TEA; TEA domain
    pfam17725
    Location:229 → 437
    YBD; YAP binding domain

  20. NM_001258769.2 → NP_001245698.1  scalloped, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245698.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q058U0, Q8IR25
    Conserved Domains (1) summary
    smart00426
    Location:23 → 90
    TEA; TEA domain

  21. NM_001272652.1 → NP_001259581.1  scalloped, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259581.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PH78
    Conserved Domains (1) summary
    smart00426
    Location:23 → 90
    TEA; TEA domain

  22. NM_206727.3 → NP_996450.1  scalloped, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996450.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q058U0, Q8IR25
    Conserved Domains (1) summary
    smart00426
    Location:23 → 90
    TEA; TEA domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A6H2EE76 A0A6H2EE76
A8JUY5 A8JUY5
A8JUY9 A8JUY9
E1JJ99 E1JJ99
M9PH78 M9PH78
P30052.1 P30052
Q8IR25 Q8IR25
Q8SZ20 Q8SZ20
X2JFL9 X2JFL9

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