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dtnba dystrobrevin, beta a [ Danio rerio (zebrafish) ]

Gene ID: 325242, updated on 12-Sep-2024

Summary

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Official Symbol
dtnbaprovided by ZNC
Official Full Name
dystrobrevin, beta aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3967
See related
Ensembl:ENSDARG00000077694 AllianceGenome:ZFIN:ZDB-GENE-030131-3967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
GDTN; dtnb; dtng; gtnb; wu:fc61h11
Summary
Predicted to enable zinc ion binding activity. Predicted to be involved in synaptic signaling. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane and synapse. Is expressed in several structures, including brain; hindbrain neural keel; myotome; presumptive diencephalon; and somite border. Orthologous to human DTNB (dystrobrevin beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See dtnba in Genome Data Viewer
Location:
chromosome: 20
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (47290001..47348161, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (47412301..47470473, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene transfer RNA threonine (anticodon CGU) Neighboring gene gastrula zinc finger protein XlCGF57.1-like Neighboring gene uncharacterized LOC137488699 Neighboring gene kinesin family member 3C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dystrobrevin and dystrophin family gene expression in zebrafish. Böhm S, et al. Gene Expr Patterns, 2008 Jan. PMID 18042440, Free PMC Article
  2. The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues and old isoforms. Jin H, et al. BMC Genomics, 2007 Jan 17. PMID 17233888, Free PMC Article
  3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dystrobrevin family gene expression in zebrafish is reported.
    Title: Dystrobrevin and dystrophin family gene expression in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in synaptic signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dystrobrevin, beta a
Names
dystrobrevin, gamma
gamma-dystrobrevin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324537.1 → NP_001311466.1  dystrobrevin, beta a isoform 2

    Status: VALIDATED

    Source sequence(s)
    CABZ01051987, CU550708, CU861885, CU861890
    UniProtKB/TrEMBL
    A0A0R4IAV8, A0A8M1P8H3
    Related
    ENSDARP00000129927.2, ENSDART00000164484.2

  2. NM_199709.2 → NP_956003.2  dystrobrevin, beta a isoform 1

    Status: VALIDATED

    Source sequence(s)
    CABZ01051987, CU550708, CU861885, CU861890
    UniProtKB/TrEMBL
    A0A8M1PA19, F1RBV6
    Related
    ENSDARP00000075308.5, ENSDART00000080863.6

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    47290001..47348161 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215384.1 → XP_068071485.1  dystrobrevin, beta a isoform X3

  2. XM_009294981.4 → XP_009293256.1  dystrobrevin, beta a isoform X1

    See identical proteins and their annotated locations for XP_009293256.1

    UniProtKB/TrEMBL
    A0A8M2BFU1
    Conserved Domains (4) summary
    cd02334
    Location:240 → 288
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 139
    EF-hand_2; EF hand
    pfam09069
    Location:143 → 230
    EF-hand_3; EF-hand
    cl23720
    Location:431 → 520
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. XM_068215383.1 → XP_068071484.1  dystrobrevin, beta a isoform X4

  4. XM_005168528.5 → XP_005168585.1  dystrobrevin, beta a isoform X3

    UniProtKB/TrEMBL
    A0A0R4IMY9, A0A8M2BGH1
    Related
    ENSDARP00000136937.1, ENSDART00000162087.2
    Conserved Domains (4) summary
    cd02334
    Location:240 → 288
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam06005
    Location:431 → 492
    DUF904; Protein of unknown function (DUF904)
    pfam09068
    Location:16 → 139
    EF-hand_2; EF hand
    pfam09069
    Location:143 → 230
    EF-hand_3; EF-hand

  5. XM_005168527.5 → XP_005168584.1  dystrobrevin, beta a isoform X2

    UniProtKB/TrEMBL
    A0A8M2BFW1
    Conserved Domains (4) summary
    cd02334
    Location:240 → 288
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 139
    EF-hand_2; EF hand
    pfam09069
    Location:143 → 230
    EF-hand_3; EF-hand
    cl23720
    Location:431 → 520
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  6. XM_005168526.5 → XP_005168583.1  dystrobrevin, beta a isoform X1

    See identical proteins and their annotated locations for XP_005168583.1

    UniProtKB/TrEMBL
    A0A8M2BFU1
    Conserved Domains (4) summary
    cd02334
    Location:240 → 288
    ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
    pfam09068
    Location:16 → 139
    EF-hand_2; EF hand
    pfam09069
    Location:143 → 230
    EF-hand_3; EF-hand
    cl23720
    Location:431 → 520
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein Strain
Heading Accession and Version

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