U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CCT6 Chaperonin containing TCP1 subunit 6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32518, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
CCT6provided by FlyBase
Official Full Name
Chaperonin containing TCP1 subunit 6provided by FlyBase
Primary source
FLYBASE:FBgn0027329
Locus tag
Dmel_CG8231
See related
AllianceGenome:FB:FBgn0027329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cct6; Cct6; CG8231; Dmel\CG8231; l(1)G0022; L(1)g0022; l(1)G0027; l(1)G0057; Q9VXQ5_DROME; Rcd3; Tcp-1-zeta; TCP-1-zeta; Tcp-1zeta; TCP-1zeta; TCP1-zeta; TCP1zeta; TCPzeta
Summary
Predicted to enable unfolded protein binding activity. Involved in centriole replication. Predicted to be part of chaperonin-containing T-complex. Is expressed in several structures, including embryonic/larval midgut primordium; germline cell; gut section; larval muscle cell; and mesoderm. Used to study intrinsic cardiomyopathy. Orthologous to several human genes including CCT6B (chaperonin containing TCP1 subunit 6B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CCT6 in Genome Data Viewer
Location:
13E13-13E14; 1-51 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15746648..15748971)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15640681..15643004)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mevalonate diphosphate decarboxylase Neighboring gene GTPase regulator associated with FAK Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and lifespan. Melkani GC, et al. FEBS Lett, 2017 Nov. PMID 28963798, Free PMC Article
  2. Structures of the Gβ-CCT and PhLP1-Gβ-CCT complexes reveal a mechanism for G-protein β-subunit folding and Gβγ dimer assembly. Plimpton RL, et al. Proc Natl Acad Sci U S A, 2015 Feb 24. PMID 25675501, Free PMC Article
  3. Chaperonin TRiC/CCT supports mitotic exit and entry into endocycle in Drosophila. Ohhara Y, et al. PLoS Genet, 2019 Apr. PMID 31034473, Free PMC Article
  4. Time-restricted feeding attenuates age-related cardiac decline in Drosophila. Gill S, et al. Science, 2015 Mar 13. PMID 25766238, Free PMC Article
  5. The hydroxyproline motif of male sex peptide elicits the innate immune response in Drosophila females. Domanitskaya EV, et al. FEBS J, 2007 Nov. PMID 17922838

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle HMP PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of chaperonin-containing T-complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
chaperonin containing TCP1 subunit 6
Names
CCT6-PA
CG8231-PA
T-cp1zeta
lethal (1) G0022
reduction in Cnn dots 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15746648..15748971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132838.3 → NP_573066.1  chaperonin containing TCP1 subunit 6 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573066.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VXQ5
    Related
    FBpp0073902
    Conserved Domains (2) summary
    cd03342
    Location:7 → 528
    TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
    TIGR02347
    Location:3 → 532
    chap_CCT_zeta; T-complex protein 1, zeta subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VXQ5 Q9VXQ5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous