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thoc5 THO complex 5 [ Danio rerio (zebrafish) ]

Gene ID: 325064, updated on 2-Nov-2024

Summary

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Official Symbol
thoc5provided by ZNC
Official Full Name
THO complex 5provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3789
See related
Ensembl:ENSDARG00000038290 AllianceGenome:ZFIN:ZDB-GENE-030131-3789
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc54b09; zgc:56190; zgc:76912; wu:fc54b09
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Predicted to act upstream of or within RNA processing; cell differentiation; and mRNA transport. Predicted to be located in cytoplasm and nuclear speck. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human THOC5 (THO complex subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See thoc5 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (3759290..3785566)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (3634053..3659907)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene prion protein, related sequence 3 Neighboring gene MORC family CW-type zinc finger 2 Neighboring gene zgc:158398 Neighboring gene chitinase domain containing 1 Neighboring gene glutamine amidotransferase class 1 domain containing 1 Neighboring gene CD151 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of Protein-Coding Gene Orthologs in Zebrafish and Mouse Inner Ear Non-sensory Supporting Cells. Giffen KP, et al. Front Neurosci, 2019. PMID 31680844, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
THO complex subunit 5 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212692.1 → NP_997857.1  THO complex subunit 5 homolog

    See identical proteins and their annotated locations for NP_997857.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066736
    UniProtKB/Swiss-Prot
    Q6NY52, Q7ZV69
    Related
    ENSDARP00000055844.4, ENSDART00000055845.7
    Conserved Domains (1) summary
    pfam09766
    Location:97 → 453
    FimP; Fms-interacting protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    3759290..3785566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470453.2 → XP_021326128.1  THO complex subunit 5 homolog isoform X1

    UniProtKB/TrEMBL
    A0A8M9PGQ7, F1RB69
    Conserved Domains (1) summary
    pfam09766
    Location:97 → 453
    FimP; Fms-interacting protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NY52.1 GenPept UniProtKB/Swiss-Prot:Q6NY52

Gene LinkOut

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