HPGD 15-hydroxyprostaglandin dehydrogenase [Homo sapiens (human)] - Gene

Summary

Official Symbol: HPGDprovided by HGNC
Official Full Name: 15-hydroxyprostaglandin dehydrogenaseprovided by HGNC
Primary source: HGNC:HGNC:5154
See related: Ensembl:ENSG00000164120 MIM:601688; AllianceGenome:HGNC:5154
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1
Summary: This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Expression: Biased expression in urinary bladder (RPKM 176.8), stomach (RPKM 67.9) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q34.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (174490175..174522893, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (177829876..177862596, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (175411326..175444044, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reclassification of the HPGD p.Ala13Glu variant causing primary hypertrophic osteoarthropathy.
Title: Reclassification of the HPGD p.Ala13Glu variant causing primary hypertrophic osteoarthropathy.
Clinical and biochemical characteristics of 12 Chinese primary hypertrophic osteoarthropathy patients with HPGD mutations.
Title: Clinical and biochemical characteristics of 12 Chinese primary hypertrophic osteoarthropathy patients with HPGD mutations.
Epigenetic Silencing of 15-Hydroxyprostaglandin Dehydrogenase by Histone Methyltransferase EHMT2/G9a in Cholangiocarcinoma.
Title: Epigenetic Silencing of 15-Hydroxyprostaglandin Dehydrogenase by Histone Methyltransferase EHMT2/G9a in Cholangiocarcinoma.
Association between COX-2 and 15-PGDH polymorphisms and SLE susceptibility.
Title: Association between COX-2 and 15-PGDH polymorphisms and SLE susceptibility.
Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength.
Title: Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength.
miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.
Title: miR-21-mediated regulation of 15-hydroxyprostaglandin dehydrogenase in colon cancer.
our results suggested that the rs2555639 of 15-PDGH was associated with colo-rectal cancer metastasis and should lead to further studies to validate the association of rs2555639 with predisposition to colorectal cancer metastasis in other groups, as well as to investigate the bio-logical functions of rs2555639 in colorectal cancer development and metastasis
Title: Single nucleotide polymorphism rs2555639 in 15-PGDH and colorectal cancer metastasis.
Down-regulation of HPGD by miR-146b-3p promotes cervical cancer cell proliferation, migration and anchorage-independent growth through activation of STAT3 and AKT pathways.
Title: Down-regulation of HPGD by miR-146b-3p promotes cervical cancer cell proliferation, migration and anchorage-independent growth through activation of STAT3 and AKT pathways.
The data indicate that HPGD-mediated suppression is a tissue- and context-dependent suppressive mechanism used by Regulatory T cells to maintain adipose tissue homeostasis.
Title: Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction.
a novel homozygous missense mutation (c.577T>C) of the human HPGD gene in all affected members of a five-generation consanguineous Pakistani family harboring primary hypertrophic osteoarthropathy
Title: A novel mutation in the HPGD gene causing primary hypertrophic osteoarthropathy with digital clubbing in a Pakistani family.

Submit: New GeneRIF Correction See all GeneRIFs (95)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 MedGen: C4551679 OMIM: 259100 GeneReviews: Not available	Compare labs
Isolated congenital digital clubbing MedGen: C0345408 OMIM: 119900 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-59688 (e-PCR)
- UniSTS:5169

RH121319 (e-PCR)
- UniSTS:138583

STS-AA032211 (e-PCR)
- UniSTS:72599

D4S3150 (e-PCR)
- UniSTS:54976

SHGC-59842 (e-PCR)
- UniSTS:38380

SHGC-67317 (e-PCR)
- UniSTS:90094

RH103965 (e-PCR)
- UniSTS:98290

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	NAS Non-traceable Author Statement more info	PubMed
enables NAD binding	IDA Inferred from Direct Assay more info	PubMed
enables NAD+ binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin E receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ductus arteriosus closure	ISS Inferred from Sequence or Structural Similarity more info
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	IDA Inferred from Direct Assay more info	PubMed
involved_in kidney development	IEA Inferred from Electronic Annotation more info
involved_in lipoxygenase pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in ovulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in parturition	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of prostaglandin catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in thrombin-activated receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: 15-hydroxyprostaglandin dehydrogenase [NAD(+)]

Names: 15-hydroxyprostaglandin dehydrogenase (NAD(+)); NAD+-dependent 15-hydroxyprostaglandin dehydrogenase; eicosanoid/docosanoid dehydrogenase; hydroxyprostaglandin dehydrogenase 15-(NAD); prostaglandin dehydrogenase 1; short chain dehydrogenase/reductase family 36C member 1

NP_000851.2

EC 1.1.1.141

EC 1.1.1.232

NP_001139288.1

EC 1.1.1.141

EC 1.1.1.232

NP_001243230.1

EC 1.1.1.141

EC 1.1.1.232

NP_001243234.1

EC 1.1.1.141

EC 1.1.1.232

NP_001243235.1

EC 1.1.1.141

EC 1.1.1.232

NP_001243236.1

EC 1.1.1.141

EC 1.1.1.232

NP_001350503.1

EC 1.1.1.141

EC 1.1.1.232

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011689.1 RefSeqGene

Range

5154..37467

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000860.6 → NP_000851.2 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1

See identical proteins and their annotated locations for NP_000851.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AC096751, AI435471, BC018986, DC420578

Consensus CDS

CCDS3821.1

UniProtKB/Swiss-Prot

B4DTA4, B4DU74, B4DV57, D3DP43, E7EV11, O00749, P15428, Q06F08, Q12998

Related

ENSP00000296522.6, ENST00000296522.11

Conserved Domains (1) summary

cd05323
Location:6 → 254

ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
NM_001145816.3 → NP_001139288.1 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 2

See identical proteins and their annotated locations for NP_001139288.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC096751, AI435471, AK300940, BC018986, DC420578, X82460

Consensus CDS

CCDS54821.1

UniProtKB/Swiss-Prot

P15428

Related

ENSP00000296521.7, ENST00000296521.11

Conserved Domains (1) summary

cd05323
Location:6 → 168

ADH_SDR_c_like; insect type alcohol dehydrogenase (ADH)-like, classical (c) SDRs
NM_001256301.1 → NP_001243230.1 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3

See identical proteins and their annotated locations for NP_001243230.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region, compared to variant 1. These differences result in translation at a downstream start codon and an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 6 encode the same protein (isoform 3).

Source sequence(s)

AI435471, AK296642, BC018986

Consensus CDS

CCDS58933.1

UniProtKB/Swiss-Prot

P15428

Related

ENSP00000422418.1, ENST00000510901.5

Conserved Domains (1) summary

cl21454
Location:1 → 133

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001256305.2 → NP_001243234.1 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 4

See identical proteins and their annotated locations for NP_001243234.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks two alternate exons in the 3' coding region, which results in a frameshift and early stop codon, compared to variant 1. It encodes isoform 4, which is shorter and contains a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC096751, AI435471, AK058013, BC018986, DC420578, U63296

Consensus CDS

CCDS58935.1

UniProtKB/Swiss-Prot

P15428

Related

ENSP00000443644.1, ENST00000542498.5

Conserved Domains (1) summary

cl25409
Location:6 → 143

SDR; Short-chain dehydrogenases/reductases (SDR)
NM_001256306.2 → NP_001243235.1 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 5

See identical proteins and their annotated locations for NP_001243235.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region, compared to variant 1. It encodes isoform 5, which is shorter but contains the same N- and C-termini, compared to isoform 1.

Source sequence(s)

AC096751, AI435471, AK300125, BC018986

Consensus CDS

CCDS58934.1

UniProtKB/Swiss-Prot

P15428

Related

ENSP00000398720.2, ENST00000422112.6

Conserved Domains (1) summary

cl25409
Location:6 → 186

SDR; Short-chain dehydrogenases/reductases (SDR)
NM_001256307.2 → NP_001243236.1 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3

See identical proteins and their annotated locations for NP_001243236.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a weak Kozak sequence and a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG, to encode an isoform (3) with a shorter N-terminus, compared to isoform 1. Variants 3 and 6 encode the same protein (isoform 3).

Source sequence(s)

AC096751, AI435471, AK300524, BC018986

Consensus CDS

CCDS58933.1

UniProtKB/Swiss-Prot

P15428

Related

ENSP00000438017.1, ENST00000541923.5

Conserved Domains (1) summary

cl21454
Location:1 → 133

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
NM_001363574.2 → NP_001350503.1 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AC096751, BX396257

Consensus CDS

CCDS87280.1

UniProtKB/TrEMBL

E9PBZ2

Related

ENSP00000420892.1, ENST00000504433.1

Conserved Domains (1) summary

cl25409
Location:6 → 141

SDR; Short-chain dehydrogenases/reductases (SDR)