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Rab3-GEF Rab3 GDP-GTP exchange factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32442, updated on 28-Oct-2024

Summary

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Official Symbol
Rab3-GEFprovided by FlyBase
Official Full Name
Rab3 GDP-GTP exchange factorprovided by FlyBase
Primary source
FLYBASE:FBgn0030613
Locus tag
Dmel_CG5627
See related
AllianceGenome:FB:FBgn0030613
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey246; BEST:GH21304; CG5627; Dmel\CG5627; rab3-gef; rab3-GEF
Summary
Predicted to enable guanyl-nucleotide exchange factor activity. Involved in cytoskeletal matrix organization at active zone. Located in neuromuscular junction of somatic muscle; neuronal cell body; and terminal bouton. Is expressed in adult head; larval brain; and larval ventral nerve cord. Orthologous to human MADD (MAP kinase activating death domain). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
all
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Genomic context

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See Rab3-GEF in Genome Data Viewer
Location:
13A10-13A12; 1-49 cM
Exon count:
24
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15089682..15113762)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14983715..15007777)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Dihydrolipoamide branched chain transacylase E2 Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 4s3 Neighboring gene drop dead Neighboring gene Ribosomal protein L37-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways. Levivier E, et al. Biochem Biophys Res Commun, 2001 Sep 28. PMID 11563850
  2. Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction. Bae H, et al. eNeuro, 2016 Mar-Apr. PMID 27022630, Free PMC Article
  3. Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology. Dourlen P, et al. Mol Psychiatry, 2017 Jun. PMID 27113998, Free PMC Article
  4. Using High-Throughput Animal or Cell-Based Models to Functionally Characterize GWAS Signals. Dourlen P, et al. Curr Genet Med Rep, 2018. PMID 30147999, Free PMC Article
  5. Non-Rodent Genetic Animal Models for Studying Tauopathy: Review of Drosophila, Zebrafish, and C. elegans Models. Giong HK, et al. Int J Mol Sci, 2021 Aug 6. PMID 34445171, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cytoskeletal matrix organization at active zone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter secretion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Rab protein signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of extrinsic apoptotic signaling pathway via death domain receptors ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vesicle-mediated transport NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuromuscular junction of somatic muscle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle NAS
Non-traceable Author Statement
more info
 PubMed 
located_in terminal bouton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rab3 GDP-GTP exchange factor
Names
CG5627-PC
CG5627-PD
CG5627-PE
CG5627-PF
CG5627-PG
CG5627-PH
CG5627-PI
CG5627-PJ
CG5627-PK
CG5627-PL
Rab3-GEF-PC
Rab3-GEF-PD
Rab3-GEF-PE
Rab3-GEF-PF
Rab3-GEF-PG
Rab3-GEF-PH
Rab3-GEF-PI
Rab3-GEF-PJ
Rab3-GEF-PK
Rab3-GEF-PL
rab3-GEF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15089682..15113762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001347810.1 → NP_001334680.1  Rab3 GDP-GTP exchange factor, isoform K [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1Z1CSK9, A0A3G1DKV1

  2. NM_001347809.1 → NP_001334679.1  Rab3 GDP-GTP exchange factor, isoform J [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1Z1CGX2, A0A3G1DKV1

  3. NM_001103513.3 → NP_001096983.2  Rab3 GDP-GTP exchange factor, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001096983.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3G1DKV1, A8JUX2
    Conserved Domains (3) summary
    smart00801
    Location:610 → 678
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:268 → 494
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:10 → 111
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  4. NM_001272631.1 → NP_001259560.1  Rab3 GDP-GTP exchange factor, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259560.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3G1DKV1, M9PEM6
    Conserved Domains (3) summary
    smart00801
    Location:613 → 681
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:260 → 486
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:10 → 111
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  5. NM_001316635.1 → NP_001303564.1  Rab3 GDP-GTP exchange factor, isoform I [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0S0X7U5, A0A3G1DKV1
    Conserved Domains (3) summary
    smart00801
    Location:613 → 681
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:260 → 486
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:10 → 111
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  6. NM_001272630.1 → NP_001259559.1  Rab3 GDP-GTP exchange factor, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259559.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3G1DKV1, M9PJN3
    Conserved Domains (3) summary
    smart00801
    Location:602 → 670
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:260 → 486
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:10 → 111
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  7. NM_132773.3 → NP_573001.2  Rab3 GDP-GTP exchange factor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573001.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8MSD8, Q9VXY2
    UniProtKB/TrEMBL
    A0A3G1DKV1
    Conserved Domains (3) summary
    smart00801
    Location:602 → 670
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:260 → 486
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:10 → 111
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  8. NM_001258746.2 → NP_001245675.1  Rab3 GDP-GTP exchange factor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245675.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3G1DKV1, M9NGF2
    Conserved Domains (3) summary
    smart00801
    Location:599 → 667
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:257 → 483
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:10 → 111
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

  9. NM_001347811.1 → NP_001334681.1  Rab3 GDP-GTP exchange factor, isoform L [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1Z1CGY3, A0A3G1DKV1

  10. NM_001258747.1 → NP_001245676.1  Rab3 GDP-GTP exchange factor, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245676.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3G1DKV1, M9NEH3
    Conserved Domains (3) summary
    smart00801
    Location:602 → 670
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00799
    Location:260 → 486
    DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
    smart00800
    Location:10 → 111
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0S0X7U5 A0A0S0X7U5
A0A1Z1CGX2 A0A1Z1CGX2
A0A1Z1CGY3 A0A1Z1CGY3
A0A1Z1CSK9 A0A1Z1CSK9
A8JUX2 A8JUX2
M9NEH3 M9NEH3
M9NGF2 M9NGF2
M9PEM6 M9PEM6
M9PJN3 M9PJN3
Q9VXY2.2 Q9VXY2

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