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usp19 ubiquitin specific peptidase 19 [ Danio rerio (zebrafish) ]

Gene ID: 324335, updated on 2-Nov-2024

Summary

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Official Symbol
usp19provided by ZNC
Official Full Name
ubiquitin specific peptidase 19provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-3055
See related
Ensembl:ENSDARG00000004132 AllianceGenome:ZFIN:ZDB-GENE-030131-3055
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fc26a05; si:dkey-32e6.9
Summary
Predicted to enable cysteine-type deubiquitinase activity and metal ion binding activity. Acts upstream of or within central nervous system morphogenesis. Predicted to be located in membrane. Orthologous to human USP19 (ubiquitin specific peptidase 19). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See usp19 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (20145141..20177559, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (20218798..20251234, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:dkey-32e6.3 Neighboring gene leucine rich repeat containing 23 Neighboring gene laminin, beta 2 (laminin S) Neighboring gene laminin, beta 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genome-Wide Identification of Laminin Family Related to Follicular Pseudoplacenta Development in Black Rockfish (Sebastes schlegelii). Zhao N, et al. Int J Mol Sci, 2022 Sep 10. PMID 36142434, Free PMC Article
  2. A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery. Tiefenbach J, et al. PLoS One, 2010 Mar 22. PMID 20339547, Free PMC Article
  3. What makes a bad egg? Egg transcriptome reveals dysregulation of translational machinery and novel fertility genes important for fertilization. Cheung CT, et al. BMC Genomics, 2019 Jul 15. PMID 31307377, Free PMC Article
  4. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within central nervous system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of protein stability IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 19
XP_005162175.1
XP_005162176.1
XP_005162177.1
XP_068072993.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    20145141..20177559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068216892.1 → XP_068072993.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X4

  2. XM_005162120.5 → XP_005162177.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X3

    UniProtKB/TrEMBL
    A0A8M2B8Y4, F1RCS0
    Related
    ENSDARP00000100933.2, ENSDART00000112840.5
    Conserved Domains (7) summary
    cd06463
    Location:59 → 140
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:427 → 523
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:1197 → 1360
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:639 → 825
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:932 → 974
    zf-MYND; MYND finger
    pfam14533
    Location:809 → 900
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:514 → 636
    USP19_linker; Linker region of USP19 deubiquitinase

  3. XM_005162119.5 → XP_005162176.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X2

    UniProtKB/TrEMBL
    A0A8M2B8X8
    Conserved Domains (7) summary
    cd06463
    Location:59 → 140
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:427 → 523
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:1195 → 1358
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:637 → 823
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:930 → 972
    zf-MYND; MYND finger
    pfam14533
    Location:807 → 898
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:514 → 634
    USP19_linker; Linker region of USP19 deubiquitinase

  4. XM_005162118.5 → XP_005162175.1  ubiquitin carboxyl-terminal hydrolase 19 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B997
    Related
    ENSDARP00000116060.1, ENSDART00000147778.2
    Conserved Domains (7) summary
    cd06463
    Location:59 → 140
    p23_like; Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including ...
    cd06466
    Location:427 → 523
    p23_CS_SGT1_like; p23_like domain similar to the C-terminal CHORD-SGT1 (CS) domain of Sgt1 (suppressor of G2 allele of Skp1). Sgt1 interacts with multiple protein complexes and has the features of a cochaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has ...
    cd02674
    Location:1197 → 1360
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:639 → 825
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam01753
    Location:932 → 974
    zf-MYND; MYND finger
    pfam14533
    Location:809 → 900
    USP7_C2; Ubiquitin-specific protease C-terminal
    pfam16602
    Location:514 → 636
    USP19_linker; Linker region of USP19 deubiquitinase
Nucleotide Protein Strain
Heading Accession and Version

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