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agap3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 [ Danio rerio (zebrafish) ]

Gene ID: 324332, updated on 18-Sep-2024

Summary

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Official Symbol
agap3provided by ZNC
Official Full Name
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-110927-1
See related
Ensembl:ENSDARG00000087822 AllianceGenome:ZFIN:ZDB-GENE-110927-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc25h09; fj34h05; wu:fc25h09; wu:fj34h05
Summary
Predicted to enable several functions, including GTP binding activity; GTPase activator activity; and GTPase activity. Predicted to be active in nucleus. Orthologous to human AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See agap3 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (34138482..34949444, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (34251180..35063564, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110438358 Neighboring gene ankyrin repeat and SOCS box containing 10 Neighboring gene gastrulation brain homeobox 1 Neighboring gene catenin (cadherin-associated protein), alpha 1 Neighboring gene leucine rich repeat transmembrane neuronal 2 Neighboring gene melanin concentrating hormone receptor 2b Neighboring gene RB1-inducible coiled-coil 1 Neighboring gene ST18 C2H2C-type zinc finger transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • KIAA0167

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ArfGAP with GTPase domain, ankyrin repeat and PH domain 3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    34138482..34949444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017353885.3 → XP_017209374.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M6YWA1

  2. XM_009297586.4 → XP_009295861.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AW63
    Conserved Domains (8) summary
    cd04103
    Location:52 → 209
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00010
    Location:50 → 215
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd00204
    Location:742 → 802
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:321 → 568
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00169
    Location:324 → 388
    PH; PH domain
    pfam01412
    Location:587 → 698
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:733 → 802
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:744 → 775
    ANK; ANK repeat [structural motif]

  3. XM_009297585.4 → XP_009295860.1  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AZA0
    Related
    ENSDARP00000106871.2, ENSDART00000128690.3
    Conserved Domains (8) summary
    cd04103
    Location:509 → 666
    Centaurin_gamma; Centaurin gamma (CENTG) GTPase
    smart00010
    Location:507 → 672
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cd00204
    Location:1199 → 1259
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd01250
    Location:778 → 1025
    PH_AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein Pleckstrin homology (PH) domain
    pfam00169
    Location:781 → 845
    PH; PH domain
    pfam01412
    Location:1044 → 1155
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:1190 → 1259
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:1201 → 1232
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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