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sp1 sp1 transcription factor [ Danio rerio (zebrafish) ]

Gene ID: 324109, updated on 2-Nov-2024

Summary

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Official Symbol
sp1provided by ZNC
Official Full Name
sp1 transcription factorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2829
See related
Ensembl:ENSDARG00000088347 AllianceGenome:ZFIN:ZDB-GENE-030131-2829
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc18h09; zgc:85950; wu:fc18h09
Summary
Enables DNA-binding transcription factor activity and double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in brain; liver; spinal cord; and testis. Orthologous to human SP1 (Sp1 transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See sp1 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (19668..28490, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (6642..28130, complement)

Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene myg1 exonuclease Neighboring gene proline rich 13 Neighboring gene collagen, type II, alpha 1b Neighboring gene integrin, alpha 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1. Lin CJ, et al. Protein Expr Purif, 2011 Mar. PMID 21040790
  2. Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status. Chen HR, et al. Chem Biol Interact, 2011 Feb 1. PMID 21167140
  3. An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra. Vogg MC, et al. Nat Commun, 2019 Jan 18. PMID 30659200, Free PMC Article
  4. An SP1-like transcription factor Spr2 acts downstream of Fgf signaling to mediate mesoderm induction. Zhao J, et al. EMBO J, 2003 Nov 17. PMID 14609954, Free PMC Article
  5. The downregulation of HSP90-controlled CRALBP expression is associated with age-related vision attenuation. Chen DD, et al. FASEB J, 2023 Mar. PMID 36826429

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A hierarchic gene expression of copper homeostatic genes was demonstrated between atp7a, sp1 and sod1 in zebrafish.
    Title: Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status.
  2. zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1
    Title: Zebrafish Sp1-like protein is structurally and functionally comparable to human Sp1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor Sp1
Names
Sp1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212662.2 → NP_997827.2  transcription factor Sp1

    Status: VALIDATED

    Source sequence(s)
    CK139903, FP326665
    UniProtKB/TrEMBL
    A0A8M1PHF3, F1QW97
    Related
    ENSDARP00000110200.1, ENSDART00000124104.2
    Conserved Domains (4) summary
    COG5048
    Location:465 → 547
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:452 → 474
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:510 → 532
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:496 → 519
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007122.7 Reference GRCz11 Primary Assembly

    Range
    19668..28490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021479551.2 → XP_021335226.1  transcription factor Sp1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z917
    Conserved Domains (3) summary
    sd00017
    Location:429 → 451
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:487 → 509
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:473 → 496
    zf-H2C2_2; Zinc-finger double domain

  2. XM_017358202.2 → XP_017213691.1  transcription factor Sp1 isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z917
    Conserved Domains (3) summary
    sd00017
    Location:429 → 451
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:487 → 509
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:473 → 496
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

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