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hspb12 heat shock protein, alpha-crystallin-related, b12 [ Danio rerio (zebrafish) ]

Gene ID: 324021, updated on 2-Nov-2024

Summary

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Official Symbol
hspb12provided by ZNC
Official Full Name
heat shock protein, alpha-crystallin-related, b12provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2741
See related
AllianceGenome:ZFIN:ZDB-GENE-030131-2741
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fc17a04; wu:fc17a04
Summary
Acts upstream of or within determination of digestive tract left/right asymmetry and determination of heart left/right asymmetry. Is expressed in cardiovascular system; pericardial region; and yolk syncytial layer. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See hspb12 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) Unplaced Scaffold NW_003336964.1 (3849..17401)
105 previous assembly GRCz10 (GCF_000002035.5) Unplaced Scaffold NW_003336964.1 (3629..16177)

NW_003336964.1Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolutionary diversity of vertebrate small heat shock proteins. Franck E, et al. J Mol Evol, 2004 Dec. PMID 15599511
  2. Small heat shock proteins Hspb7 and Hspb12 regulate early steps of cardiac morphogenesis. Rosenfeld GE, et al. Dev Biol, 2013 Sep 15. PMID 23850773, Free PMC Article
  3. Small heat shock proteins are necessary for heart migration and laterality determination in zebrafish. Lahvic JL, et al. Dev Biol, 2013 Dec 15. PMID 24140541, Free PMC Article
  4. Hspb7 is a cardioprotective chaperone facilitating sarcomeric proteostasis. Mercer EJ, et al. Dev Biol, 2018 Mar 1. PMID 29331499, Free PMC Article
  5. Developmental expression patterns of the zebrafish small heat shock proteins. Marvin M, et al. Dev Dyn, 2008 Feb. PMID 18161059

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of hspb7 or hspb12 disrupts ventricular cardiomyocyte development.
    Title: Small heat shock proteins Hspb7 and Hspb12 regulate early steps of cardiac morphogenesis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within determination of digestive tract left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of heart left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of heart left/right asymmetry IPI
Inferred from Physical Interaction
more info
 PubMed 
acts_upstream_of_or_within heart development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within left/right pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
heat shock protein, alpha-crystallin-related, b12; uncharacterized protein hspb12
Names
small heat shock protein Hspb12

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NW_003336964.1 Reference GRCz11 Primary Assembly

    Range
    3849..17401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003201714.5 → XP_003201762.1  uncharacterized protein hspb12

    UniProtKB/TrEMBL
    A0A8M1RPE6
    Conserved Domains (1) summary
    cd06479
    Location:115 → 195
    ACD_HspB7_like; Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB7, also known as cardiovascular small heat shock protein (cvHsp), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect ...
Nucleotide Protein Strain
Heading Accession and Version

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