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Fbxl4 F box and leucine-rich-repeat gene 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32378, updated on 2-Nov-2024

Summary

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Official Symbol
Fbxl4provided by FlyBase
Official Full Name
F box and leucine-rich-repeat gene 4provided by FlyBase
Primary source
FLYBASE:FBgn0030555
Locus tag
Dmel_CG1839
See related
AllianceGenome:FB:FBgn0030555
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1839; dFbxl4; Dmel\CG1839; fbxl4; FBXL4
Summary
Involved in several processes, including negative regulation of cell communication; negative regulation of circadian sleep/wake cycle, sleep; and protein polyubiquitination. Located in neuron projection and neuronal cell body. Is expressed in eye and retina. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 13. Orthologous to human FBXL4 (F-box and leucine rich repeat protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Fbxl4 in Genome Data Viewer
Location:
12E5-12E5; 1-48 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (14234413..14237923, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (14128446..14131956, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L38 Neighboring gene uncharacterized protein Neighboring gene Dihydrouridine synthase 2 Neighboring gene mRNA-capping-enzyme

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A potential dimerization region of dCAMTA is critical for termination of fly visual response. Gong P, et al. J Biol Chem, 2007 Jul 20. PMID 17537720
  2. A novel family of calmodulin-binding transcription activators in multicellular organisms. Bouché N, et al. J Biol Chem, 2002 Jun 14. PMID 11925432
  3. Light/Clock Influences Membrane Potential Dynamics to Regulate Sleep States. Tabuchi M, et al. Front Neurol, 2021. PMID 33854471, Free PMC Article
  4. SnapShot: F box proteins I. Skaar JR, et al. Cell, 2009 Jun 12. PMID 19524517
  5. Fbxl4 Serves as a Clock Output Molecule that Regulates Sleep through Promotion of Rhythmic Degradation of the GABA(A) Receptor. Li Q, et al. Curr Biol, 2017 Dec 4. PMID 29174887

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISM
Inferred from Sequence Model
more info
  
involved_in negative regulation of circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of opsin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SCF ubiquitin ligase complex ISM
Inferred from Sequence Model
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
F box and leucine-rich-repeat gene 4
Names
CG1839-PA
Fbxl4-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    14234413..14237923 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132723.3 → NP_572951.1  F box and leucine-rich-repeat gene 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572951.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0S4, Q9VY46
    Related
    FBpp0073740
    Conserved Domains (4) summary
    cd09293
    Location:552 → 660
    AMN1; Antagonist of mitotic exit network protein 1
    cd00116
    Location:437 → 641
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00034
    Location:449 → 474
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:326 → 372
    F-box-like; F-box-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VY46 Q9VY46

Gene LinkOut

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