U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ankhb ANKH inorganic pyrophosphate transport regulator b [ Danio rerio (zebrafish) ]

Gene ID: 323738, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ankhbprovided by ZNC
Official Full Name
ANKH inorganic pyrophosphate transport regulator bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2458
See related
Ensembl:ENSDARG00000014969 AllianceGenome:ZFIN:ZDB-GENE-030131-2458
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ankh; wu:fc08d03
Summary
Predicted to enable inorganic diphosphate transmembrane transporter activity and phosphate transmembrane transporter activity. Predicted to be involved in regulation of bone mineralization. Predicted to act upstream of or within phosphate ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant craniometaphyseal dysplasia and chondrocalcinosis. Orthologous to human ANKH (ANKH inorganic pyrophosphate transport regulator). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ankhb in Genome Data Viewer
Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (31957615..32006312)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (31974397..32023094)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene amphiphysin Neighboring gene OTU deubiquitinase with linear linkage specificity b Neighboring gene si:ch211-139k8.2 Neighboring gene MYC proto-oncogene, bHLH transcription factor b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolutionary history of c-myc in teleosts and characterization of the duplicated c-myca genes in goldfish embryos. Marandel L, et al. Mol Reprod Dev, 2012 Feb. PMID 22213278
  2. Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia. Nürnberg P, et al. Nat Genet, 2001 May. PMID 11326272
  3. Generation and Validation of a Complete Knockout Model of abcc6a in Zebrafish. Van Gils M, et al. J Invest Dermatol, 2018 Nov. PMID 30030150
  4. Role of the mouse ank gene in control of tissue calcification and arthritis. Ho AM, et al. Science, 2000 Jul 14. PMID 10894769
  5. Macrophage-stimulating protein and calcium homeostasis in zebrafish. Huitema LF, et al. FASEB J, 2012 Oct. PMID 22787265, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC91789

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables inorganic diphosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphate ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphate ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
progressive ankylosis protein homolog B
Names
ANK-B
ankylosis, progressive homolog b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_194370.1 → NP_919351.1  progressive ankylosis protein homolog B

    See identical proteins and their annotated locations for NP_919351.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ302035
    UniProtKB/Swiss-Prot
    B0UY66, P58368, Q66I27
    Related
    ENSDARP00000002526.7, ENSDART00000012413.8
    Conserved Domains (2) summary
    pfam07260
    Location:1 → 345
    ANKH; Progressive ankylosis protein (ANKH)
    cl09326
    Location:327 → 438
    MATE_like; Multidrug and toxic compound extrusion family and similar proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    31957615..32006312
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P58368.2 GenPept UniProtKB/Swiss-Prot:P58368

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous