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stx4 syntaxin 4 [ Danio rerio (zebrafish) ]

Gene ID: 323735, updated on 2-Nov-2024

Summary

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Official Symbol
stx4provided by ZNC
Official Full Name
syntaxin 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-2455
See related
Ensembl:ENSDARG00000052518 AllianceGenome:ZFIN:ZDB-GENE-030131-2455
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
STX4A; zgc:56272; wu:fc08c10; si:dkey-220f10.3
Summary
Predicted to enable SNAP receptor activity and SNARE binding activity. Acts upstream of or within detection of mechanical stimulus; response to auditory stimulus; and startle response. Predicted to be located in membrane. Predicted to be part of SNARE complex. Predicted to be active in endomembrane system and plasma membrane. Is expressed in cardiac muscle cell. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness. Orthologous to human STX4 (syntaxin 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See stx4 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (20627651..20640165)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (20505777..20518291)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene arylsulfatase G Neighboring gene sorting nexin 11 Neighboring gene si:dkey-220f10.4 Neighboring gene calcium binding and coiled-coil domain 2 Neighboring gene SNF8 subunit of ESCRT-II

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Syntaxin 4 is essential for hearing in human and zebrafish. Schrauwen I, et al. Hum Mol Genet, 2023 Mar 20. PMID 36355422, Free PMC Article
  2. Stx4 is required to regulate cardiomyocyte Ca(2+) handling during vertebrate cardiac development. Perl E, et al. HGG Adv, 2022 Jul 14. PMID 35599850, Free PMC Article
  3. In vivo imaging of molecular interactions at damaged sarcolemma. Roostalu U, et al. Dev Cell, 2012 Mar 13. PMID 22421042
  4. In vivo proteomic mapping through GFP-directed proximity-dependent biotin labelling in zebrafish. Xiong Z, et al. Elife, 2021 Feb 16. PMID 33591275, Free PMC Article
  5. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Syntaxin 4 is essential for hearing in human and zebrafish.
    Title: Syntaxin 4 is essential for hearing in human and zebrafish.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC56272

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within detection of mechanical stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to auditory stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within startle response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
syntaxin-4
Names
syntaxin 4A (placental)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200221.1 → NP_956515.1  syntaxin-4

    See identical proteins and their annotated locations for NP_956515.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046039
    UniProtKB/TrEMBL
    Q6TLF5, Q7ZV18
    Related
    ENSDARP00000068873.4, ENSDART00000074384.5
    Conserved Domains (3) summary
    cd00179
    Location:41 → 190
    SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
    cd15883
    Location:200 → 262
    SNARE_syntaxin4; SNARE motif of syntaxin 4
    pfam00804
    Location:41 → 236
    Syntaxin; Syntaxin

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    20627651..20640165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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