jub Ajuba LIM protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: jubprovided by FlyBase
Official Full Name: Ajuba LIM proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0030530
Locus tag: Dmel_CG11063
See related: AllianceGenome:FB:FBgn0030530
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Ajuba; CG11063; djub; dJub; Djub; Dmel\CG11063; Jub; JUB
Summary: Enables protein sequestering activity. Involved in several processes, including negative regulation of hippo signaling; positive regulation of imaginal disc growth; and protein localization to centrosome. Located in adherens junction and apical cortex. Colocalizes with apical part of cell and pericentriolar material. Is expressed in interommatidial cell. Orthologous to several human genes including WTIP (WT1 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 12C6-12C6; 1-46 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13826041..13830317, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13720074..13724350, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The study observations establish Jub as a reporter of tension experienced at adherens junctions, and identify distinct types of tension-dependent and tension-independent junctional complexes.
Title: Organization and function of tension-dependent complexes at adherens junctions.
our findings indicate that a-Cat acts through multiple mechanisms to control tissue growth, including regulation of AJ stability, mechanosensitive Ajuba recruitment, and dynamic direct F-actin interactions.
Title: Role of α-Catenin and its mechanosensing properties in regulating Hippo/YAP-dependent tissue growth.
These results demonstrate that Ajuba plays an essential role in regulating cell adhesion in response to mechanical forces generated by epithelial morphogenesis.
Title: The force-sensitive protein Ajuba regulates cell adhesion during epithelial morphogenesis.
Study reports that increasing tension within the cytoskeleton increases Drosophila wing growth, whereas decreasing cytoskeletal tension decreases wing growth; Jub associates with alpha-catenin and that its localization to adherens junctions and association with alpha-catenin are promoted by cytoskeletal tension. Jub recruits Warts to junctions in a tension-dependent manner.
Title: Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex.
A molecular mechanism linking JNK activity to Yki regulation. JNK can promote YAP activity in mammalian cells.
Title: Ajuba family proteins link JNK to Hippo signaling.
Mutation in jub leads to centrosome separation defects and aberrant mitotic spindles.
Title: Drosophila Ajuba is not an Aurora-A activator but is required to maintain Aurora-A at the centrosome.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein sequestering activity	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to centrosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in apical cortex	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with apical part of cell	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with pericentriolar material	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ajuba LIM protein

Names: CG11063-PB; CG11063-PC; CG11063-PD; CG11063-PE; ajuba; ajuba LIM; djub; drosophila ajuba LIM protein; jub-PB; jub-PC; jub-PD; jub-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13826041..13830317 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001298303.1 → NP_001285232.1 ajuba LIM protein, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285232.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MSC9, M9ZYW5

Conserved Domains (3) summary

cd09352
Location:506 → 559

LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins

cd09355
Location:571 → 623

LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins

cd09438
Location:631 → 692

LIM3_Ajuba_like; The third LIM domain of Ajuba-like proteins
NM_001201657.2 → NP_001188586.1 ajuba LIM protein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188586.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MSC9, M9ZYW5

Conserved Domains (3) summary

cd09352
Location:506 → 559

LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins

cd09355
Location:571 → 623

LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins

cd09438
Location:631 → 692

LIM3_Ajuba_like; The third LIM domain of Ajuba-like proteins
NM_001201658.2 → NP_001188587.1 ajuba LIM protein, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188587.1

Status: REVIEWED

UniProtKB/TrEMBL

M9MSA2, M9ZYW5

Conserved Domains (3) summary

cd09352
Location:506 → 559

LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins

cd09355
Location:576 → 628

LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins

cd09438
Location:636 → 697

LIM3_Ajuba_like; The third LIM domain of Ajuba-like proteins
NM_132702.5 → NP_572930.3 ajuba LIM protein, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_572930.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8SZR9, Q9VY77

UniProtKB/TrEMBL

M9ZYW5

Conserved Domains (3) summary

cd09352
Location:516 → 569

LIM1_Ajuba_like; The first LIM domain of Ajuba-like proteins

cd09355
Location:581 → 633

LIM2_Ajuba_like; The second LIM domain of Ajuba-like proteins

cd09438
Location:641 → 702

LIM3_Ajuba_like; The third LIM domain of Ajuba-like proteins