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CG15743 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32279, updated on 18-Sep-2024

Summary

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Official Symbol
CG15743provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030465
Locus tag
Dmel_CG15743
See related
AllianceGenome:FB:FBgn0030465
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG15743
Summary
Predicted to enable 3'-nucleotidase activity. Predicted to be involved in dephosphorylation. Located in endomembrane system. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; organism; and salivary gland body primordium. Human ortholog(s) of this gene implicated in chondrodysplasia with joint dislocations gPAPP type. Orthologous to human BPNT2 (3'(2'), 5'-bisphosphate nucleotidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG15743 in Genome Data Viewer
Location:
11E9-11E9; 1-42 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13285707..13287741)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13179740..13181774)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene comatose Neighboring gene Histone deacetylase 4 Neighboring gene Remoulade Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Organ-specific gene expression: the bHLH protein Sage provides tissue specificity to Drosophila FoxA. Fox RM, et al. Development, 2013 May. PMID 23578928, Free PMC Article
  2. Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling. Ermanoska B, et al. Nat Commun, 2023 Mar 8. PMID 36890170, Free PMC Article
  3. Sensitivity of the distribution of mutational fitness effects to environment, genetic background, and adaptedness: a case study with Drosophila. Wang AD, et al. Evolution, 2014 Mar. PMID 24206451
  4. A conserved myotubularin-related phosphatase regulates autophagy by maintaining autophagic flux. Allen EA, et al. J Cell Biol, 2020 Nov 2. PMID 32915229, Free PMC Article
  5. CRISPR/Cas9 mediated genetic resource for unknown kinase and phosphatase genes in Drosophila. Wu M, et al. Sci Rep, 2020 Apr 30. PMID 32355295, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3'-nucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG15743-PA
CG15743-PB
CG15743-PC
NP_001259511.1
NP_001285197.1
NP_572869.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13285707..13287741
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298268.1 → NP_001285197.1  uncharacterized protein Dmel_CG15743, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285197.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYF2
    UniProtKB/TrEMBL
    M9PH13
    Conserved Domains (1) summary
    cd01640
    Location:59 → 342
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...

  2. NM_132641.2 → NP_572869.1  uncharacterized protein Dmel_CG15743, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572869.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYF2
    UniProtKB/TrEMBL
    M9PH13
    Related
    FBpp0073586
    Conserved Domains (1) summary
    cd01640
    Location:59 → 342
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...

  3. NM_001272582.1 → NP_001259511.1  uncharacterized protein Dmel_CG15743, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259511.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYF2
    UniProtKB/TrEMBL
    M9PH13
    Conserved Domains (1) summary
    cd01640
    Location:59 → 342
    IPPase; IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PH13 M9PH13
Q9VYF2.1 Q9VYF2

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