U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

septin6 septin 6 [ Danio rerio (zebrafish) ]

Gene ID: 322694, updated on 14-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
septin6provided by ZNC
Official Full Name
septin 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1414
See related
Ensembl:ENSDARG00000010721 AllianceGenome:ZFIN:ZDB-GENE-030131-1414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Sep2; sept6; fc54b04; zgc:66071; wu:fb70g05; wu:fc54b04; wu:fl76c07
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Acts upstream of or within cilium assembly and determination of left/right symmetry. Located in cilium. Is expressed in several structures, including Kupffer's vesicle; axis; hypochord; nervous system; and pronephros. Orthologous to human SEPTIN6 (septin 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See septin6 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (33297781..33327986, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (32957467..32987712, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene START domain containing 14 Neighboring gene RAB41, member RAS oncogene family Neighboring gene small nucleolar RNA SNORA69 Neighboring gene sosondowah ankyrin repeat domain family d Neighboring gene ribosomal protein L39

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Sept6 is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development. Zhai G, et al. Mol Cell Biol, 2014 Apr. PMID 24469395, Free PMC Article
  2. Zebrafish null mutants of Sept6 and Sept15 are viable but more susceptible to Shigella infection. Torraca V, et al. Cytoskeleton (Hoboken), 2023 Jul-Aug. PMID 36855298, Free PMC Article
  3. Phylogenetic and evolutionary analysis of the septin protein family in metazoan. Cao L, et al. FEBS Lett, 2007 Nov 27. PMID 17967425
  4. Comparative Proteome Research in a Zebrafish Model for Vanishing White Matter Disease. Kim D, et al. Int J Mol Sci, 2021 Mar 8. PMID 33800130, Free PMC Article
  5. Analysis of septins across kingdoms reveals orthology and new motifs. Pan F, et al. BMC Evol Biol, 2007 Jul 1. PMID 17601340, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of digestive tract left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of heart left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of liver left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of pancreatic left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
septin-6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212626.2 → NP_997791.2  septin-6

    Status: VALIDATED

    Source sequence(s)
    BX571981
    UniProtKB/TrEMBL
    A0A8M2BL09, F1R3Q3
    Related
    ENSDARP00000121708.1, ENSDART00000137997.3
    Conserved Domains (2) summary
    cd01850
    Location:45 → 312
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:25 → 378
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    33297781..33327986 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173240.5 → XP_005173297.1  septin-6 isoform X3

    UniProtKB/TrEMBL
    A0A8M2BKJ7
    Conserved Domains (2) summary
    cd01850
    Location:45 → 312
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:25 → 378
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  2. XM_068213160.1 → XP_068069261.1  septin-6 isoform X1

  3. XM_005173239.4 → XP_005173296.1  septin-6 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BKJ6
    Conserved Domains (2) summary
    cd01850
    Location:45 → 312
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:25 → 378
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

  4. XM_005173242.5 → XP_005173299.1  septin-6 isoform X4

    UniProtKB/TrEMBL
    A0A8M2BL09, F1R3Q3
    Conserved Domains (2) summary
    cd01850
    Location:45 → 312
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:25 → 378
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RNA

  1. XR_225093.5 RNA Sequence

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394917.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    262798..291832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools