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acta2 actin alpha 2, smooth muscle [ Danio rerio (zebrafish) ]

Gene ID: 322509, updated on 5-Oct-2024

Summary

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Official Symbol
acta2provided by ZNC
Official Full Name
actin alpha 2, smooth muscleprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1229
See related
Ensembl:ENSDARG00000045180 AllianceGenome:ZFIN:ZDB-GENE-030131-1229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb63d03
Summary
Acts upstream of or within heart contraction. Predicted to be located in several cellular components, including cell body; filopodium; and lamellipodium. Predicted to be part of dynactin complex. Is expressed in several structures, including cardiovascular system; gut; mesoderm; musculature system; and swim bladder. Human ortholog(s) of this gene implicated in Moyamoya disease; megacystis-microcolon-intestinal hypoperistalsis syndrome; and thoracic aortic aneurysm. Orthologous to several human genes including ACTA2 (actin alpha 2, smooth muscle). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See acta2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (17100473..17115730)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (16978609..16993856)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene interferon-induced protein with tetratricopeptide repeats 9 Neighboring gene cholesterol 25-hydroxylase Neighboring gene STAM binding protein-like 1 Neighboring gene ankyrin repeat domain 22

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Graded effects of unregulated smooth muscle myosin on intestinal architecture, intestinal motility and vascular function in zebrafish. Abrams J, et al. Dis Model Mech, 2016 May 1. PMID 26893369, Free PMC Article
  2. The agrochemical S-metolachlor disrupts molecular mediators and morphology of the swim bladder: Implications for locomotor activity in zebrafish (Danio rerio). Yang L, et al. Ecotoxicol Environ Saf, 2021 Jan 15. PMID 33396161
  3. Evaluation and comparison of the mitochondrial and developmental toxicity of three strobilurins in zebrafish embryo/larvae. Yang L, et al. Environ Pollut, 2021 Feb 1. PMID 33360065
  4. Differential effects of thin and thick filament disruption on zebrafish smooth muscle regulatory proteins. Davuluri G, et al. Neurogastroenterol Motil, 2010 Oct. PMID 20591105, Free PMC Article
  5. Characterization of vascular mural cells during zebrafish development. Santoro MM, et al. Mech Dev, 2009 Aug-Sep. PMID 19539756, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood circulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesenchyme migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in filopodium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
actin, aortic smooth muscle
Names
actin, alpha 2, smooth muscle, aorta
sma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212620.2 → NP_997785.2  actin, aortic smooth muscle

    Status: VALIDATED

    Source sequence(s)
    BC075896, EB864489
    UniProtKB/TrEMBL
    A0A8M1PH82, Q6DHS1
    Related
    ENSDARP00000143706.1, ENSDART00000177923.2
    Conserved Domains (1) summary
    PTZ00281
    Location:4 → 377
    PTZ00281; actin; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    17100473..17115730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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