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nqo1 NAD(P)H dehydrogenase, quinone 1 [ Danio rerio (zebrafish) ]

Gene ID: 322506, updated on 28-Oct-2024

Summary

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Official Symbol
nqo1provided by ZNC
Official Full Name
NAD(P)H dehydrogenase, quinone 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1226
See related
Ensembl:ENSDARG00000010250 AllianceGenome:ZFIN:ZDB-GENE-030131-1226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:77191; wu:fb63c10
Summary
Predicted to enable NAD(P)H dehydrogenase (quinone) activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be active in cytosol. Is expressed in several structures, including head; liver; neuromast; pleuroperitoneal region; and yolk. Human ortholog(s) of this gene implicated in several diseases, including agranulocytosis; breast cancer (multiple); hematologic cancer (multiple); lung disease (multiple); and small cell carcinoma. Orthologous to several human genes including NQO1 (NAD(P)H quinone dehydrogenase 1). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
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Genomic context

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See nqo1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (56703251..56722320)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (56401843..56420909)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily G, member 4b Neighboring gene beta-1,3-galactosyltransferase 2-like Neighboring gene kiaa0895l Neighboring gene casein kinase 2, alpha prime polypeptide a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The expression of zebrafish NAD(P)H:quinone oxidoreductase 1(nqo1) in adult organs and embryos. Liu M, et al. Gene Expr Patterns, 2020 Dec. PMID 32889095
  2. The chemical defensome of five model teleost fish. Eide M, et al. Sci Rep, 2021 May 18. PMID 34006915, Free PMC Article
  3. The impact of ZnO nanoparticle aggregates on the embryonic development of zebrafish (Danio rerio). Zhu X, et al. Nanotechnology, 2009 May 13. PMID 19420631
  4. Caveolae sense oxidative stress through membrane lipid peroxidation and cytosolic release of CAVIN1 to regulate NRF2. Wu Y, et al. Dev Cell, 2023 Mar 13. PMID 36858041
  5. Relationship between Neuroprotective Effects and Structure of Procyanidins. Chen J, et al. Molecules, 2022 Apr 2. PMID 35408708, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The expression of zebrafish NAD(P)H:quinone oxidoreductase 1(nqo1) in adult organs and embryos.
    Title: The expression of zebrafish NAD(P)H:quinone oxidoreductase 1(nqo1) in adult organs and embryos.
  2. Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt and JNK/Nrf2/NQO1 pathway.
    Title: Activation of Akt and JNK/Nrf2/NQO1 pathway contributes to the protective effect of coptisine against AAPH-induced oxidative stress.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables NAD(P)H dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD(P)H dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NAD(P)H dehydrogenase [quinone] 1
NP_001191201.1
NP_991105.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204272.2 → NP_001191201.1  NAD(P)H dehydrogenase [quinone] 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX255936
    UniProtKB/TrEMBL
    A0A2R8PW65, A0A8M1NYZ9
    Related
    ENSDARP00000145161.1, ENSDART00000184547.1
    Conserved Domains (1) summary
    pfam02525
    Location:7 → 226
    Flavodoxin_2; Flavodoxin-like fold

  2. NM_205542.3 → NP_991105.1  NAD(P)H dehydrogenase [quinone] 1 isoform 2

    See identical proteins and their annotated locations for NP_991105.1

    Status: VALIDATED

    Source sequence(s)
    BX255936
    UniProtKB/TrEMBL
    A0A8M1PJR2, Q6P0H2
    Related
    ENSDARP00000021150.6, ENSDART00000004964.8
    Conserved Domains (1) summary
    pfam02525
    Location:7 → 212
    Flavodoxin_2; Flavodoxin-like fold

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    56703251..56722320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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