adh8a alcohol dehydrogenase 8a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adh8aprovided by ZNC
Official Full Name: alcohol dehydrogenase 8aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030529-3
See related: Ensembl:ENSDARG00000091211 AllianceGenome:ZFIN:ZDB-GENE-030529-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:66178; zgc:77878; wu:fb62f02
Summary: Enables alcohol dehydrogenase (NAD+) activity. Acts upstream of or within cellular response to xenobiotic stimulus and ethanol metabolic process. Predicted to be active in cytosol. Is expressed in female organism; intestine; liver; and ovary. Human ortholog(s) of this gene implicated in alcohol use disorder; late onset Parkinson's disease; and pancreatic cancer. Orthologous to several human genes including ADH1A (alcohol dehydrogenase 1A (class I), alpha polypeptide); ADH1B (alcohol dehydrogenase 1B (class I), beta polypeptide); and ADH1C (alcohol dehydrogenase 1C (class I), gamma polypeptide). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 13

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (12653974..12660364, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (12521499..12527889, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transient overexpression of adh8a increases allyl alcohol toxicity in zebrafish embryos.
Title: Transient overexpression of adh8a increases allyl alcohol toxicity in zebrafish embryos.
ADH8a and ADH8b from zebrafish are conserved among species and expressed in developmental and adult tissue
Title: Two zebrafish alcohol dehydrogenases share common ancestry with mammalian class I, II, IV, and V alcohol dehydrogenase genes but have distinct functional characteristics.

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General gene information

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Markers

fb62f02.x1 (e-PCR)
- UniSTS:203394

fb62d02.x1 (e-PCR)
- UniSTS:190888

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within alcohol metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ethanol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in formaldehyde catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alcohol dehydrogenase 8a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001946.4 → NP_001001946.3 alcohol dehydrogenase 8a

See identical proteins and their annotated locations for NP_001001946.3

Status: VALIDATED

Source sequence(s)

BC065464, CR559943

UniProtKB/TrEMBL

A0A8M1MZQ9, Q6P0S5

Related

ENSDARP00000024643.7, ENSDART00000008498.8

Conserved Domains (2) summary

COG1062
Location:8 → 372

FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

cl16912
Location:8 → 374

MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family