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chs1 chitin synthase 1 [ Danio rerio (zebrafish) ]

Gene ID: 322468, updated on 18-Sep-2024

Summary

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Official Symbol
chs1provided by ZNC
Official Full Name
chitin synthase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1188
See related
Ensembl:ENSDARG00000068515 AllianceGenome:ZFIN:ZDB-GENE-030131-1188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb62c02; wu:fb62c02; si:zfos-1762d12.1
Summary
Predicted to enable chitin synthase activity. Acts upstream of or within chitin biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cell periphery and cell septum. Is expressed in epidermis; intestinal epithelium; intestine lumen; and scale. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See chs1 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (285874..303139, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (155673..172936, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 30 member 6 Neighboring gene mitochondrial pyruvate carrier 1 Neighboring gene interferon regulatory factor 1a Neighboring gene DEAD (Asp-Glu-Ala-Asp) box helicase 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Chitin is endogenously produced in vertebrates. Tang WJ, et al. Curr Biol, 2015 Mar 30. PMID 25772447, Free PMC Article
  2. Zebrafish IRF1 regulates IFN antiviral response through binding to IFNϕ1 and IFNϕ3 promoters downstream of MyD88 signaling. Feng H, et al. J Immunol, 2015 Feb 1. PMID 25535281
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables chitin synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chitin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chitin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chitin synthase 1
NP_001303255.1
XP_009305300.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316326.1 → NP_001303255.1  chitin synthase 1

    Status: VALIDATED

    Source sequence(s)
    CU694274
    UniProtKB/TrEMBL
    A0A8M1P739, E7F1A0
    Related
    ENSDARP00000089905.5, ENSDART00000099131.6
    Conserved Domains (4) summary
    COG1215
    Location:689 → 969
    BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
    pfam08463
    Location:1190 → 1313
    EcoEI_R_C; EcoEI R protein C-terminal
    cl11394
    Location:505 → 846
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    cl12079
    Location:858 → 981
    DUF373; Domain of unknown function (DUF373)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    285874..303139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009307025.4 → XP_009305300.1  chitin synthase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M3B7R6
    Conserved Domains (4) summary
    COG1215
    Location:689 → 969
    BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
    pfam08463
    Location:1189 → 1312
    EcoEI_R_C; EcoEI R protein C-terminal
    cl11394
    Location:505 → 846
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
    cl12079
    Location:858 → 981
    DUF373; Domain of unknown function (DUF373)
Nucleotide Protein Strain
Heading Accession and Version

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