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cpb1 carboxypeptidase B1 (tissue) [ Danio rerio (zebrafish) ]

Gene ID: 322412, updated on 17-Aug-2024

Summary

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Official Symbol
cpb1provided by ZNC
Official Full Name
carboxypeptidase B1 (tissue)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1132
See related
Ensembl:ENSDARG00000045442 AllianceGenome:ZFIN:ZDB-GENE-030131-1132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fb60d07; wu:fb69b08
Summary
Predicted to enable metallocarboxypeptidase activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be active in extracellular space. Is expressed in liver. Orthologous to several human genes including CPB1 (carboxypeptidase B1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (4755389..4765724, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (4723602..4733937, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene frizzled class receptor 8a Neighboring gene uncharacterized LOC103909738 Neighboring gene angiotensin II receptor, type 1b Neighboring gene zic family member 1 (odd-paired homolog, Drosophila)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding. Lyons PJ, et al. PLoS One, 2010 Sep 24. PMID 20885977, Free PMC Article
  2. Knockout of zebrafish colony-stimulating factor 1 receptor by CRISPR/Cas9 affects metabolism and locomotion capacity. Meng H, et al. Biochem Biophys Res Commun, 2021 Apr 30. PMID 33725575
  3. Proteomic analysis of arsenic-exposed zebrafish (Danio rerio) identifies altered expression in proteins involved in fibrosis and lipid uptake in a gender-specific manner. Carlson P, et al. Toxicol Sci, 2013 Jul. PMID 23570992
  4. Differential embryotoxicity of the organic pollutants in rural and urban air particles. Mesquita SR, et al. Environ Pollut, 2015 Nov. PMID 26298234
  5. Intestinal Serum amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization. Murdoch CC, et al. PLoS Pathog, 2019 Mar. PMID 30845179, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carboxypeptidase B
Names
zte141
NP_001103491.2
NP_001315354.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110021.2 → NP_001103491.2  carboxypeptidase B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in its 5' UTR, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AL935306
    UniProtKB/TrEMBL
    A0A8M1NG52

  2. NM_001328425.1 → NP_001315354.1  carboxypeptidase B isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL935306, BC067637, EE688842
    UniProtKB/TrEMBL
    A0A0R4ILM4, A0A8M1P961, F1QJN9, Q6NWD1
    Related
    ENSDARP00000109376.2, ENSDART00000121576.4
    Conserved Domains (2) summary
    cd03871
    Location:112 → 412
    M14_CPB; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B subgroup
    pfam02244
    Location:27 → 99
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    4755389..4765724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395164.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    198450..208785 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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