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cs citrate synthase [ Danio rerio (zebrafish) ]

Gene ID: 322339, updated on 2-Nov-2024

Summary

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Official Symbol
csprovided by ZNC
Official Full Name
citrate synthaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-1058
See related
Ensembl:ENSDARG00000103364 AllianceGenome:ZFIN:ZDB-GENE-030131-1058
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55507; wu:fb58e04
Summary
Predicted to enable citrate (Si)-synthase activity and identical protein binding activity. Acts upstream of or within response to activity. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial matrix. Is expressed in brain; gill; heart; and muscle. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and hypertrophic cardiomyopathy. Orthologous to human CS (citrate synthase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 23
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (33907899..33928316)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (33981368..34001785)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene Rac GTPase activating protein 1 Neighboring gene inactive dipeptidyl peptidase 10 Neighboring gene si:ch211-148l7.4 Neighboring gene coenzyme Q10A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The metabolic regulator PGC-1α directly controls the expression of the hypothalamic neuropeptide oxytocin. Blechman J, et al. J Neurosci, 2011 Oct 19. PMID 22016516, Free PMC Article
  2. Effects of chronic dietary selenomethionine exposure on repeat swimming performance, aerobic metabolism and methionine catabolism in adult zebrafish (Danio rerio). Thomas JK, et al. Aquat Toxicol, 2013 Apr 15. PMID 23399444
  3. Growth hormone overexpression generates an unfavorable phenotype in juvenile transgenic zebrafish under hypoxic conditions. Almeida DV, et al. Gen Comp Endocrinol, 2013 Dec 1. PMID 24055561
  4. Differential mitochondrial dysregulation by exposure to individual organochlorine pesticides (OCPs) and their mixture in zebrafish embryos. Lee H, et al. Environ Pollut, 2021 May 15. PMID 33714130
  5. Exercise quantity-dependent muscle hypertrophy in adult zebrafish (Danio rerio). Hasumura T, et al. J Comp Physiol B, 2016 Jul. PMID 26951149

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
  
enables citrate (Si)-synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables citrate (Si)-synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables citrate (Si)-synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within citrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial matrix ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
citrate synthase, mitochondrial
Names
citrate (Si)-synthase
NP_955892.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199598.1 → NP_955892.1  citrate synthase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_955892.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045362
    UniProtKB/Swiss-Prot
    Q7ZVY5
    UniProtKB/TrEMBL
    B2GT34
    Related
    ENSDARP00000135698.1, ENSDART00000159445.2
    Conserved Domains (2) summary
    cd06105
    Location:35 → 462
    ScCit1-2_like; Saccharomyces cerevisiae (Sc) citrate synthases Cit1-2_like. Citrate synthases (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) with oxaloacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or ...
    PLN02456
    Location:7 → 456
    PLN02456; citrate synthase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    33907899..33928316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZVY5.1 GenPept UniProtKB/Swiss-Prot:Q7ZVY5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.