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sulf2b sulfatase 2b [ Danio rerio (zebrafish) ]

Gene ID: 322056, updated on 2-Nov-2024

Summary

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Official Symbol
sulf2bprovided by ZNC
Official Full Name
sulfatase 2bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-775
See related
Ensembl:ENSDARG00000013838 AllianceGenome:ZFIN:ZDB-GENE-030131-775
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
SULF2; sulf2l; wu:fb48e04; si:dkeyp-84g9.1
Summary
Predicted to enable N-acetylglucosamine-6-sulfatase activity and glycosaminoglycan binding activity. Acts upstream of with a positive effect on epithelial structure maintenance. Predicted to be located in Golgi stack and extracellular space. Predicted to be active in cell surface; endoplasmic reticulum; and plasma membrane. Is expressed in several structures, including central nervous system; head; neural rod; segmental plate; and somite. Orthologous to human SULF2 (sulfatase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See sulf2b in Genome Data Viewer
Location:
chromosome: 23
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (15203819..15563586, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (15447742..15807504, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene PHD finger protein 20, b Neighboring gene Rho GTPase activating protein 46b Neighboring gene uncharacterized LOC137489105 Neighboring gene uncharacterized LOC100034569 Neighboring gene uncharacterized LOC137489104 Neighboring gene uncharacterized LOC137489106 Neighboring gene uncharacterized LOC137489179 Neighboring gene uncharacterized LOC137489180

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dynamic expression patterns of 6-O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2. Gorsi B, et al. Dev Dyn, 2010 Dec. PMID 20981828
  2. Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord. Danesin C, et al. Sci Rep, 2021 Jan 8. PMID 33420239, Free PMC Article
  3. Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish. Schenk H, et al. Biomed Res Int, 2019. PMID 31428635, Free PMC Article
  4. Genomewide expression profiling in the zebrafish embryo identifies target genes regulated by Hedgehog signaling during vertebrate development. Xu J, et al. Genetics, 2006 Oct. PMID 16888327, Free PMC Article
  5. A screen for hoxb1-regulated genes identifies ppp1r14al as a regulator of the rhombomere 4 Fgf-signaling center. Choe SK, et al. Dev Biol, 2011 Oct 15. PMID 21787765, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zebrafish sulf1 and sulf2a are broadly expressed in the central nervous system (CNS) and non-neuronal tissue including heart, somite boundaries, olfactory system, and otic vesicle.
    Title: Dynamic expression patterns of 6-O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acetylglucosamine-6-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arylsulfatase activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfuric ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in bone development IEA
Inferred from Electronic Annotation
more info
  
involved_in chondrocyte development IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic skeletal system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_positive_effect epithelial structure maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_positive_effect epithelial structure maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in esophagus smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in glial cell-derived neurotrophic factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in glomerular basement membrane development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innervation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of vascular endothelial growth factor production IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
  
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
extracellular sulfatase Sulf-2b
Names
sulf2a
sulfatase 2, like
sulfatase FP2a
sulfatase FP2b
NP_001003833.3
XP_017208998.1
XP_017208999.1
XP_017209000.1
XP_021325410.1
XP_068072775.1
XP_068072776.1
XP_068072777.1
XP_068072778.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003833.3 → NP_001003833.3  extracellular sulfatase Sulf-2b precursor

    Status: VALIDATED

    Source sequence(s)
    BX537335, CR759764
    Related
    ENSDARP00000036209.5, ENSDART00000035865.7

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    15203819..15563586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068216675.1 → XP_068072776.1  extracellular sulfatase Sulf-2b isoform X1

  2. XM_017353510.3 → XP_017208999.1  extracellular sulfatase Sulf-2b isoform X1

    UniProtKB/TrEMBL
    A0A8M6YXM3, Q6EF98
    Conserved Domains (3) summary
    cd16147
    Location:45 → 387
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:551 → 676
    DUF3740; Sulfatase protein
    cl23718
    Location:764 → 813
    ALP_like; alkaline phosphatases and sulfatases

  3. XM_017353511.3 → XP_017209000.1  extracellular sulfatase Sulf-2b isoform X1

    UniProtKB/TrEMBL
    A0A8M6YXM3, Q6EF98
    Conserved Domains (3) summary
    cd16147
    Location:45 → 387
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:551 → 676
    DUF3740; Sulfatase protein
    cl23718
    Location:764 → 813
    ALP_like; alkaline phosphatases and sulfatases

  4. XM_017353509.2 → XP_017208998.1  extracellular sulfatase Sulf-2b isoform X1

    UniProtKB/TrEMBL
    A0A8M6YXM3, Q6EF98
    Conserved Domains (3) summary
    cd16147
    Location:45 → 387
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:551 → 676
    DUF3740; Sulfatase protein
    cl23718
    Location:764 → 813
    ALP_like; alkaline phosphatases and sulfatases

  5. XM_068216674.1 → XP_068072775.1  extracellular sulfatase Sulf-2b isoform X1

  6. XM_021469735.2 → XP_021325410.1  extracellular sulfatase Sulf-2b isoform X1

    UniProtKB/TrEMBL
    A0A8M6YXM3, Q6EF98
    Conserved Domains (3) summary
    cd16147
    Location:45 → 387
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
    pfam12548
    Location:551 → 676
    DUF3740; Sulfatase protein
    cl23718
    Location:764 → 813
    ALP_like; alkaline phosphatases and sulfatases

  7. XM_068216676.1 → XP_068072777.1  extracellular sulfatase Sulf-2b isoform X2

    Related
    ENSDARP00000121392.1, ENSDART00000139135.2

  8. XM_068216677.1 → XP_068072778.1  extracellular sulfatase Sulf-2b isoform X3

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395137.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    222009..307373 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395359.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    234844..304976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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