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eif2s1a eukaryotic translation initiation factor 2, subunit 1 alpha a [ Danio rerio (zebrafish) ]

Gene ID: 321807, updated on 2-Nov-2024

Summary

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Official Symbol
eif2s1aprovided by ZNC
Official Full Name
eukaryotic translation initiation factor 2, subunit 1 alpha aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-526
See related
Ensembl:ENSDARG00000005827 AllianceGenome:ZFIN:ZDB-GENE-030131-526
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Eif2s1; eif2s1l; fb36a08; zgc:56510; wu:fb36a08
Summary
Predicted to enable ribosome binding activity and translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within translation. Predicted to be located in cytoplasm. Predicted to be part of eukaryotic 48S preinitiation complex and eukaryotic translation initiation factor 2 complex. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See eif2s1a in Genome Data Viewer
Location:
chromosome: 17
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (34244345..34254233)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (34296399..34306287)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909052 Neighboring gene gephyrin a Neighboring gene protein associated with LIN7 1, MAGUK p55 family member a Neighboring gene uncharacterized LOC137488124 Neighboring gene uncharacterized LOC103909053 Neighboring gene uncharacterized LOC137488125

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cloning, expression and functional analysis of PKR from grass carp (Ctenopharyngodon idellus). Hu YS, et al. Fish Shellfish Immunol, 2013 Dec. PMID 24084043
  2. Characterization of a ranavirus inhibitor of the antiviral protein kinase PKR. Rothenburg S, et al. BMC Microbiol, 2011 Mar 18. PMID 21418572, Free PMC Article
  3. Triclocarban at environmentally relevant concentrations induces the endoplasmic reticulum stress in zebrafish. Zhou T, et al. Environ Toxicol, 2019 Mar. PMID 30592132
  4. N-acetylcysteine protects against microcystin-LR-induced endoplasmic reticulum stress and germ cell apoptosis in zebrafish testes. Zhao S, et al. Chemosphere, 2018 Aug. PMID 29679867
  5. Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish. Crouzier L, et al. Int J Mol Sci, 2021 Oct 13. PMID 34681705, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translational initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic stress granule IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 2 subunit 1a
Names
eukaryotic translation initiation factor 2, subunit 1 alpha, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199569.1 → NP_955863.1  eukaryotic translation initiation factor 2 subunit 1a

    See identical proteins and their annotated locations for NP_955863.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049468
    UniProtKB/TrEMBL
    Q6P134, Q7ZWD3
    Related
    ENSDARP00000026560.8, ENSDART00000006058.9
    Conserved Domains (3) summary
    cd04452
    Location:14 → 89
    S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
    PTZ00248
    Location:4 → 315
    PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional
    pfam07541
    Location:131 → 241
    EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    34244345..34254233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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