Hsc70-3 Heat shock protein 70 cognate 3 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsc70-3provided by FlyBase
Official Full Name: Heat shock protein 70 cognate 3provided by FlyBase
Primary source: FLYBASE:FBgn0001218
Locus tag: Dmel_CG4147
See related: AllianceGenome:FB:FBgn0001218
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A4V4C4_DROME; anon-WO0138581.7; bip; Bip; BiP; BIP; CG1579; CG4147; dBip; dBiP; dhsc70; Dmel\CG4147; dmHsc72; grp78; Grp78; GRP78; GRP87/Bip; Hsc-3; HSC-70; Hsc-70-3; hsc3; Hsc3; HSC3; Hsc3-BiP/GRP78; Hsc3p; hsc70; Hsc70; HSC70; hsc70-3; HSC70-3; Hsc70.3; hsc72; Hsc73; Hsp-c3; HSP70; HSP70er1; HSP7C_DROME; HSPA5; l(1)G0102; l(1)G0111; l(1)G0292; l(1)G0341; l(1)G0407; l(1)G0466
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Involved in RNA interference; intestinal stem cell homeostasis; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum and extracellular space. Part of endoplasmic reticulum chaperone complex. Is expressed in adult head; adult heart; spermatozoon; and wing disc. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (Hsp70) member 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 10E3-10E4; 1-36 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (11801696..11807117, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (11695729..11701150, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info
enables protein-transporting ATPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sleep	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	HDA more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	NAS Non-traceable Author Statement more info	PubMed
part_of endoplasmic reticulum chaperone complex	IBA Inferred from Biological aspect of Ancestor more info
part_of endoplasmic reticulum chaperone complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in endoplasmic reticulum lumen	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock protein 70 cognate 3

Names: 70 kDa heat shock protein, endoplasmic reticulum 1; CG4147-PA; CG4147-PB; CG4147-PC; CG4147-PD; CG4147-PE; GRP78; Hsc70-3-PA; Hsc70-3-PB; Hsc70-3-PC; Hsc70-3-PD; Hsc70-3-PE; glucose-regulated protein 78kD/binding immunoglobulin protein; heat shock 70-kDa protein cognate 3; heat shock cognate protein 3; heat shock protein cognate 3; heat shock protein cognate 70-3; heat shock protein cognate 72; heat-shock cognate 70-3; immunoglobulin binding protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

11801696..11807117 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078577.3 → NP_511132.2 heat shock protein 70 cognate 3, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511132.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4C4, P29844, Q86NM3, Q9VYU2, Q9VYU3

UniProtKB/TrEMBL

F3YDH0

Related

FBpp0073445

Conserved Domains (2) summary

cd10241
Location:29 → 403

HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins

PTZ00009
Location:32 → 643

PTZ00009; heat shock 70 kDa protein; Provisional
NM_167306.2 → NP_727563.1 heat shock protein 70 cognate 3, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727563.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4C4, P29844, Q86NM3, Q9VYU2, Q9VYU3

UniProtKB/TrEMBL

F3YDH0

Related

FBpp0073446

Conserved Domains (2) summary

cd10241
Location:29 → 403

HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins

PTZ00009
Location:32 → 643

PTZ00009; heat shock 70 kDa protein; Provisional
NM_167308.2 → NP_727565.1 heat shock protein 70 cognate 3, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727565.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4C4, P29844, Q86NM3, Q9VYU2, Q9VYU3

UniProtKB/TrEMBL

F3YDH0

Related

FBpp0073447

Conserved Domains (2) summary

cd10241
Location:29 → 403

HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins

PTZ00009
Location:32 → 643

PTZ00009; heat shock 70 kDa protein; Provisional
NM_167307.2 → NP_727564.1 heat shock protein 70 cognate 3, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727564.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4C4, P29844, Q86NM3, Q9VYU2, Q9VYU3

UniProtKB/TrEMBL

F3YDH0

Related

FBpp0073448

Conserved Domains (2) summary

cd10241
Location:29 → 403

HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins

PTZ00009
Location:32 → 643

PTZ00009; heat shock 70 kDa protein; Provisional
NM_001298210.1 → NP_001285139.1 heat shock protein 70 cognate 3, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285139.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V4C4, P29844, Q86NM3, Q9VYU2, Q9VYU3

UniProtKB/TrEMBL

F3YDH0

Conserved Domains (2) summary

cd10241
Location:29 → 403

HSPA5-like_NBD; Nucleotide-binding domain of human HSPA5 and similar proteins

PTZ00009
Location:32 → 643

PTZ00009; heat shock 70 kDa protein; Provisional