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paics phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase [ Danio rerio (zebrafish) ]

Gene ID: 321193, updated on 2-Nov-2024

Summary

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Official Symbol
paicsprovided by ZNC
Official Full Name
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9762
See related
Ensembl:ENSDARG00000033539 AllianceGenome:ZFIN:ZDB-GENE-030131-9762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb293; sb:cb293; wu:fa28a05
Summary
Predicted to enable phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Acts upstream of or within chordate embryonic development; pigmentation; and retina development in camera-type eye. Is expressed in several structures, including eye; immature eye; midbrain; neural tube; and yolk syncytial layer. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
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Genomic context

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See paics in Genome Data Viewer
Location:
chromosome: 20
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (25618116..25631256, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (25719026..25726972, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily J, polypeptide 20 Neighboring gene uncharacterized LOC110438177 Neighboring gene uncharacterized LOC137488651 Neighboring gene uncharacterized LOC137488652 Neighboring gene phosphoribosyl pyrophosphate amidotransferase Neighboring gene si:dkeyp-117h8.4 Neighboring gene aminoadipate-semialdehyde dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development. Ng A, et al. Development, 2009 Aug. PMID 19570845, Free PMC Article
  2. An iterative genetic and dynamical modelling approach identifies novel features of the gene regulatory network underlying melanocyte development. Greenhill ER, et al. PLoS Genet, 2011 Sep. PMID 21909283, Free PMC Article
  3. Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism. Weger M, et al. EBioMedicine, 2018 Oct. PMID 30266295, Free PMC Article
  4. Toxicological assessment of trace β-diketone antibiotic mixtures on zebrafish (Danio rerio) by proteomic analysis. Yin X, et al. PLoS One, 2014. PMID 25062015, Free PMC Article
  5. Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Lewis VM, et al. Proc Natl Acad Sci U S A, 2019 Jun 11. PMID 31138706, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two recessive zebrafish mutations that affect de novo purine synthesis, gart and paics, were analyzed.
    Title: Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazole carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pigmentation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Names
multifunctional protein ADE2
NP_955831.1
XP_068071481.1
XP_068071482.1
XP_068071483.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199537.3 → NP_955831.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

    See identical proteins and their annotated locations for NP_955831.1

    Status: VALIDATED

    Source sequence(s)
    CR352243
    UniProtKB/TrEMBL
    F6NHZ6, F6NI72, Q7ZUN6
    Related
    ENSDARP00000120562.1, ENSDART00000136475.3
    Conserved Domains (2) summary
    cd01416
    Location:7 → 258
    SAICAR_synt_Ade5; Ade5_like 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase
    TIGR01162
    Location:268 → 421
    purE; phosphoribosylaminoimidazole carboxylase, PurE protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    25618116..25631256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068215380.1 → XP_068071481.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X1

    Related
    ENSDARP00000048163.5, ENSDART00000048164.6

  2. XM_068215381.1 → XP_068071482.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2

    Related
    ENSDARP00000116949.1, ENSDART00000132247.3

  3. XM_068215382.1 → XP_068071483.1  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2

    Related
    ENSDARP00000109219.2, ENSDART00000126716.4
Nucleotide Protein Strain
Heading Accession and Version

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