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pabpc4 poly(A) binding protein, cytoplasmic 4 (inducible form) [ Danio rerio (zebrafish) ]

Gene ID: 321035, updated on 28-Oct-2024

Summary

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Official Symbol
pabpc4provided by ZNC
Official Full Name
poly(A) binding protein, cytoplasmic 4 (inducible form)provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-9663
See related
Ensembl:ENSDARG00000059259 AllianceGenome:ZFIN:ZDB-GENE-030131-9663
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb12; sb:cb12
Summary
Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in eye; musculature system; solid lens vesicle; and somite. Orthologous to several human genes including PABPC4 (poly(A) binding protein cytoplasmic 4). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs
human mouse all
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Genomic context

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See pabpc4 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (25305584..25326690, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (25287183..25308365, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB domain containing 11 Neighboring gene peptidylprolyl isomerase E (cyclophilin E) Neighboring gene zona pellucida protein C Neighboring gene transmembrane protein 54a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Poly(A)-binding proteins are required for microRNA-mediated silencing and to promote target deadenylation in C. elegans. Flamand MN, et al. Nucleic Acids Res, 2016 Jul 8. PMID 27095199, Free PMC Article
  2. Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish. Mishima Y, et al. Proc Natl Acad Sci U S A, 2012 Jan 24. PMID 22232654, Free PMC Article
  3. Reconstruction of a 450-My-old ancestral vertebrate protokaryotype. Kohn M, et al. Trends Genet, 2006 Apr. PMID 16517001
  4. Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation. Ozbudak EM, et al. Proc Natl Acad Sci U S A, 2010 Mar 2. PMID 20160088, Free PMC Article
  5. An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. Fouchécourt S, et al. BMC Evol Biol, 2019 Jul 3. PMID 31269894, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(U) RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
polyadenylate-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201296.1 → NP_958453.1  polyadenylate-binding protein 4

    See identical proteins and their annotated locations for NP_958453.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053126
    UniProtKB/TrEMBL
    A0A8M1PJ34, Q7T3G5
    Related
    ENSDARP00000140050.1, ENSDART00000168822.3
    Conserved Domains (6) summary
    TIGR01628
    Location:12 → 614
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12378
    Location:13 → 92
    RRM1_I_PABPs; RNA recognition motif 1 in type I polyadenylate-binding proteins
    cd12379
    Location:98 → 173
    RRM2_I_PABPs; RNA recognition motif 2 found in type I polyadenylate-binding proteins
    cd12380
    Location:191 → 270
    RRM3_I_PABPs; RNA recognition motif 3 found in type I polyadenylate-binding proteins
    cd12381
    Location:294 → 371
    RRM4_I_PABPs; RNA recognition motif 4 in type I polyadenylate-binding proteins
    pfam00658
    Location:546 → 613
    PABP; Poly-adenylate binding protein, unique domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    25305584..25326690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021467109.2 → XP_021322784.1  polyadenylate-binding protein 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PE33
    Conserved Domains (1) summary
    TIGR01628
    Location:12 → 609
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394991.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    232507..253257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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