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Evi5 Ecotropic viral integration site 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32088, updated on 18-Sep-2024

Summary

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Official Symbol
Evi5provided by FlyBase
Official Full Name
Ecotropic viral integration site 5provided by FlyBase
Primary source
FLYBASE:FBgn0262740
Locus tag
Dmel_CG11727
See related
AllianceGenome:FB:FBgn0262740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH08923; BcDNA:LD11130; CG11727; Dmel\CG11727; MRE21
Summary
Enables GTPase activator activity and small GTPase binding activity. Involved in regulation of GTPase activity; regulation of cell migration; and regulation of protein localization. Located in Golgi apparatus and vesicle. Colocalizes with recycling endosome. Is expressed in several structures, including extended germ band embryo; foregut; larval ventral nerve cord; pole plasm; and presumptive embryonic/larval central nervous system. Orthologous to several human genes including EVI5 (ecotropic viral integration site 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Evi5 in Genome Data Viewer
Location:
10B11-10B14; 1-34 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11430523..11454386, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11324556..11348419, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Odorant receptor 10a Neighboring gene Gustatory receptor 10a Neighboring gene Glutamine synthetase 2 Neighboring gene Sphingosine kinase 1 Neighboring gene Heterochromatin protein 5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vitro and in vivo characterization of the Rab11-GAP activity of Drosophila Evi5. Laflamme C, et al. Methods Mol Biol, 2015. PMID 25800843
  2. Confirming candidate genes for longevity by RT-qPCR using two different genetic backgrounds and selection methods. Wit J, et al. J Insect Physiol, 2013 Mar. PMID 23357090
  3. Prediction of intestinal stem cell regulatory genes from Drosophila gut damage model created using multiple inducers: Differential gene expression-based protein-protein interaction network analysis. Lee SH, et al. Dev Comp Immunol, 2023 Jan. PMID 36087786
  4. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article
  5. Identification and expression analysis of putative mRNA-like non-coding RNA in Drosophila. Inagaki S, et al. Genes Cells, 2005 Dec. PMID 16324153

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila Evi5 is a critical regulator of intracellular iron transport via transferrin and ferritin interactions.
    Title: Drosophila Evi5 is a critical regulator of intracellular iron transport via transferrin and ferritin interactions.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activator activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of cell migration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein localization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ecotropic viral integration site 5
Names
CG11727-PA
CG11727-PB
CG11727-PC
CG11727-PD
CG11727-PE
Evi5-PA
Evi5-PB
Evi5-PC
Evi5-PD
Evi5-PE
ecotropic viral integration site 5 ortholog
mRNA-like ncRNA in embryogenesis 21

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    11430523..11454386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_167285.4 → NP_727526.2  ecotropic viral integration site 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727526.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C9QP48, E1JJH7, F0JAJ2, Q8IR89, Q8MT90, Q95S00, Q9VYY9
    Conserved Domains (2) summary
    smart00164
    Location:113 → 320
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam15030
    Location:627 → 731
    DUF4527; Protein of unknown function (DUF4527)

  2. NM_001169251.4 → NP_001162722.1  ecotropic viral integration site 5, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162722.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYY9
    Conserved Domains (3) summary
    cl14654
    Location:377 → 517
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00164
    Location:113 → 320
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam15030
    Location:621 → 725
    DUF4527; Protein of unknown function (DUF4527)

  3. NM_001272521.1 → NP_001259450.1  ecotropic viral integration site 5, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259450.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYY9
    Conserved Domains (3) summary
    cl14654
    Location:377 → 517
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00164
    Location:113 → 320
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam15030
    Location:621 → 725
    DUF4527; Protein of unknown function (DUF4527)

  4. NM_001169250.2 → NP_001162721.1  ecotropic viral integration site 5, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162721.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYY9
    Conserved Domains (3) summary
    cl14654
    Location:377 → 517
    V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
    smart00164
    Location:113 → 320
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam15030
    Location:621 → 725
    DUF4527; Protein of unknown function (DUF4527)

  5. NM_132488.5 → NP_572716.3  ecotropic viral integration site 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572716.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VYY9
    Conserved Domains (2) summary
    smart00164
    Location:113 → 320
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    pfam15030
    Location:627 → 731
    DUF4527; Protein of unknown function (DUF4527)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95NS4 Q95NS4
Q9VYY9.3 Q9VYY9

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