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Atp2b3 ATPase, Ca++ transporting, plasma membrane 3 [ Mus musculus (house mouse) ]

Gene ID: 320707, updated on 2-Nov-2024

Summary

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Official Symbol
Atp2b3provided by MGI
Official Full Name
ATPase, Ca++ transporting, plasma membrane 3provided by MGI
Primary source
MGI:MGI:1347353
See related
Ensembl:ENSMUSG00000031376 AllianceGenome:MGI:1347353
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pmca3; 6430519O13Rik
Summary
Predicted to enable P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration and PDZ domain binding activity. Predicted to be involved in calcium ion export across plasma membrane and regulation of cytosolic calcium ion concentration. Predicted to be located in parallel fiber. Predicted to be active in several cellular components, including GABA-ergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1. Orthologous to human ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 35.0), genital fat pad adult (RPKM 15.6) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Atp2b3 in Genome Data Viewer
Location:
X A7.3; X 37.33 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72546356..72632267)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73502749..73573275)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene HAUS augmin-like complex, subunit 7 Neighboring gene biglycan Neighboring gene cyclin Q, pseudogene 1 Neighboring gene predicted gene, 46680 Neighboring gene dual specificity phosphatase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Plasma membrane calcium ATPases as critical regulators of calcium homeostasis during neuronal cell function. Garcia ML, et al. Front Biosci, 1999 Dec 1. PMID 10577388
  2. PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growth†. Savy V, et al. Biol Reprod, 2022 Dec 10. PMID 36130203, Free PMC Article
  3. Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons. Krizaj D, et al. J Comp Neurol, 2002 Sep 9. PMID 12209837, Free PMC Article
  4. The plasma membrane calcium pump in health and disease. Brini M, et al. FEBS J, 2013 Nov. PMID 23413890
  5. Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange. Reuter H, et al. Cell Calcium, 2003 Jul. PMID 12767889

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in parallel fiber ISO
Inferred from Sequence Orthology
more info
  
is_active_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
  
located_in parallel fiber to Purkinje cell synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
plasma membrane calcium-transporting ATPase 3
NP_001297466.1
NP_796210.2
XP_006528144.1
XP_006528147.1
XP_006528149.1
XP_011245911.1
XP_011245912.1
XP_011245913.1
XP_011245914.1
XP_011245915.1
XP_011245916.1
XP_030107234.1
XP_036017880.1
XP_036017881.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310537.1 → NP_001297466.1  plasma membrane calcium-transporting ATPase 3 isoform 2

    See identical proteins and their annotated locations for NP_001297466.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK032322, AL805924, AW048876, BB643948
    Consensus CDS
    CCDS85778.1
    UniProtKB/TrEMBL
    Q0VF54, Q8C048
    Related
    ENSMUSP00000033744.6, ENSMUST00000033744.12
    Conserved Domains (7) summary
    TIGR01517
    Location:19 → 1061
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:164 → 462
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:877 → 1055
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:51 → 121
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:1100 → 1114
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:684 → 803
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:523 → 612
    Cation_ATPase; Cation transport ATPase (P-type)

  2. NM_177236.4 → NP_796210.2  plasma membrane calcium-transporting ATPase 3 isoform 1

    See identical proteins and their annotated locations for NP_796210.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AK032322, AK045516, AL805924
    Consensus CDS
    CCDS30205.1
    UniProtKB/TrEMBL
    Q0VF54, Q0VF55
    Related
    ENSMUSP00000085775.2, ENSMUST00000088429.8
    Conserved Domains (7) summary
    TIGR01517
    Location:19 → 1061
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam00122
    Location:164 → 462
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:877 → 1055
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam00690
    Location:51 → 121
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    pfam12424
    Location:1100 → 1147
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    pfam12710
    Location:684 → 803
    HAD; haloacid dehalogenase-like hydrolase
    pfam13246
    Location:523 → 612
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72546356..72632267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161988.1 → XP_036017881.1  plasma membrane calcium-transporting ATPase 3 isoform X6

    UniProtKB/TrEMBL
    Q0VF54
    Conserved Domains (2) summary
    TIGR01517
    Location:19 → 1061
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1100 → 1114
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  2. XM_006528081.3 → XP_006528144.1  plasma membrane calcium-transporting ATPase 3 isoform X1

    See identical proteins and their annotated locations for XP_006528144.1

    UniProtKB/TrEMBL
    Q0VF54
    Conserved Domains (2) summary
    TIGR01517
    Location:19 → 1061
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1100 → 1175
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  3. XM_011247612.2 → XP_011245914.1  plasma membrane calcium-transporting ATPase 3 isoform X2

    UniProtKB/TrEMBL
    Q0VF54
    Conserved Domains (2) summary
    TIGR01517
    Location:19 → 1047
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1086 → 1161
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  4. XM_006528084.5 → XP_006528147.1  plasma membrane calcium-transporting ATPase 3 isoform X4

    UniProtKB/TrEMBL
    A2ALL9, Q0VF54
    Related
    ENSMUSP00000110123.2, ENSMUST00000114479.2
    Conserved Domains (2) summary
    TIGR01517
    Location:19 → 1061
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1100 → 1145
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  5. XM_011247614.4 → XP_011245916.1  plasma membrane calcium-transporting ATPase 3 isoform X5

    UniProtKB/TrEMBL
    Q0VF54
    Conserved Domains (2) summary
    TIGR01517
    Location:19 → 1047
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1086 → 1131
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  6. XM_006528086.4 → XP_006528149.1  plasma membrane calcium-transporting ATPase 3 isoform X7

    UniProtKB/TrEMBL
    Q0VF54
    Conserved Domains (2) summary
    TIGR01517
    Location:19 → 1061
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1100 → 1114
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  7. XM_030251374.2 → XP_030107234.1  plasma membrane calcium-transporting ATPase 3 isoform X8

    UniProtKB/TrEMBL
    Q0VF54
    Conserved Domains (2) summary
    TIGR01517
    Location:19 → 1047
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1086 → 1100
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  8. XM_011247613.3 → XP_011245915.1  plasma membrane calcium-transporting ATPase 3 isoform X3

    UniProtKB/TrEMBL
    Q0VF54
    Conserved Domains (2) summary
    TIGR01517
    Location:19 → 1047
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1086 → 1132
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  9. XM_036161987.1 → XP_036017880.1  plasma membrane calcium-transporting ATPase 3 isoform X2

    UniProtKB/TrEMBL
    Q0VF54
    Conserved Domains (2) summary
    TIGR01517
    Location:19 → 1047
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1086 → 1161
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  10. XM_011247610.2 → XP_011245912.1  plasma membrane calcium-transporting ATPase 3 isoform X1

    See identical proteins and their annotated locations for XP_011245912.1

    UniProtKB/TrEMBL
    Q0VF54
    Conserved Domains (2) summary
    TIGR01517
    Location:19 → 1061
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1100 → 1175
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  11. XM_011247609.4 → XP_011245911.1  plasma membrane calcium-transporting ATPase 3 isoform X1

    See identical proteins and their annotated locations for XP_011245911.1

    UniProtKB/TrEMBL
    Q0VF54
    Conserved Domains (2) summary
    TIGR01517
    Location:19 → 1061
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1100 → 1175
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  12. XM_011247611.3 → XP_011245913.1  plasma membrane calcium-transporting ATPase 3 isoform X1

    See identical proteins and their annotated locations for XP_011245913.1

    UniProtKB/TrEMBL
    Q0VF54
    Conserved Domains (2) summary
    TIGR01517
    Location:19 → 1061
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1100 → 1175
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

RNA

  1. XR_004940342.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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