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Skint4 selection and upkeep of intraepithelial T cells 4 [ Mus musculus (house mouse) ]

Gene ID: 320640, updated on 17-Aug-2024

Summary

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Official Symbol
Skint4provided by MGI
Official Full Name
selection and upkeep of intraepithelial T cells 4provided by MGI
Primary source
MGI:MGI:2444425
See related
Ensembl:ENSMUSG00000055960 AllianceGenome:MGI:2444425
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9530098N22Rik
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in appendicular skeleton; heart ventricle; skin; and thymus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Skint4 in Genome Data Viewer
Location:
4 D1; 4 51.53 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (111929213..112025273)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (112072016..112168076)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene selection and upkeep of intraepithelial T cells 7 Neighboring gene selection and upkeep of intraepithelial T cells 1 Neighboring gene STARR-seq mESC enhancer starr_11099 Neighboring gene selection and upkeep of intraepithelial T cells 3 Neighboring gene selection and upkeep of intraepithelial T cells 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells. Boyden LM, et al. Nat Genet, 2008 May. PMID 18408721, Free PMC Article
  2. The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development. Bebee TW, et al. Elife, 2015 Sep 15. PMID 26371508, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
selection and upkeep of intraepithelial T-cells protein 4
Names
skint 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347180.1 → NP_001334109.1  selection and upkeep of intraepithelial T-cells protein 4 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL831778
    Consensus CDS
    CCDS84779.1
    UniProtKB/Swiss-Prot
    A7TZF3, A7TZF4
    Related
    ENSMUSP00000102175.2, ENSMUST00000106565.8

  2. NM_001357339.1 → NP_001344268.1  selection and upkeep of intraepithelial T-cells protein 4 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AK028550, AK028795, EF494898
    Conserved Domains (2) summary
    cd05713
    Location:49 → 148
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    cl11960
    Location:160 → 249
    Ig; Immunoglobulin domain

  3. NM_178786.4 → NP_848901.2  selection and upkeep of intraepithelial T-cells protein 4 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK028795, AK035748, AK162813
    Consensus CDS
    CCDS38837.1
    UniProtKB/TrEMBL
    E9QLU2
    Related
    ENSMUSP00000102176.2, ENSMUST00000106566.2
    Conserved Domains (2) summary
    cd05713
    Location:49 → 148
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:41 → 147
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    111929213..112025273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A7TZF3.1 GenPept UniProtKB/Swiss-Prot:A7TZF3

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