HOXA10 homeobox A10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: HOXA10provided by HGNC
Official Full Name: homeobox A10provided by HGNC
Primary source: HGNC:HGNC:5100
See related: Ensembl:ENSG00000253293 MIM:142957; AllianceGenome:HGNC:5100
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PL; HOX1; HOX1H; HOX1.8
Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]
Expression: Biased expression in endometrium (RPKM 36.7), prostate (RPKM 13.4) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p15.2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (27170605..27179861, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (27306614..27315870, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (27210224..27219480, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

m6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance and malignant progression of laryngeal squamous cell carcinoma through regulating Notch and Keap1/Nrf2 pathways.
Title: m6A/HOXA10-AS/ITGA6 axis aggravates oxidative resistance and malignant progression of laryngeal squamous cell carcinoma through regulating Notch and Keap1/Nrf2 pathways.
Endometrial Injury Upregulates Expression of Receptivity Genes in Women with Implantation Failure.
Title: Endometrial Injury Upregulates Expression of Receptivity Genes in Women with Implantation Failure.
Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma in vitro and in vivo.
Title: Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma in vitro and in vivo.
Long non-coding RNA Homeobox D gene cluster antisense growth-associated long noncoding RNA/microRNA-182-5p/Homeobox protein A10 alleviates postmenopausal osteoporosis via accelerating osteoblast differentiation of bone marrow mesenchymal stem cells.
Title: Long non-coding RNA Homeobox D gene cluster antisense growth-associated long noncoding RNA/microRNA-182-5p/Homeobox protein A10 alleviates postmenopausal osteoporosis via accelerating osteoblast differentiation of bone marrow mesenchymal stem cells.
A Novel HOXA10-Associated 5-Gene-Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma.
Title: A Novel HOXA10-Associated 5-Gene-Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma.
Expression of HOXA10 Gene in Women with Endometriosis: A Systematic Review.
Title: Expression of HOXA10 Gene in Women with Endometriosis: A Systematic Review.
Integrated Bioinformatic Analysis of the Correlation of HOXA10 Expression with Survival and Immune Cell Infiltration in Lower Grade Glioma.
Title: Integrated Bioinformatic Analysis of the Correlation of HOXA10 Expression with Survival and Immune Cell Infiltration in Lower Grade Glioma.
LncRNA HOXA10-AS promotes the progression of esophageal carcinoma by regulating the expression of HOXA10.
Title: LncRNA HOXA10-AS promotes the progression of esophageal carcinoma by regulating the expression of HOXA10.
HOXA10 promote pancreatic cancer progression via directly activating canonical NF-kappaB signaling pathway.
Title: HOXA10 promote pancreatic cancer progression via directly activating canonical NF-κB signaling pathway.
Serum 25-hydroxyvitamin D correlates with endometrial HOXA10 mRNA expression.
Title: Serum 25-hydroxyvitamin D correlates with endometrial HOXA10 mRNA expression.

Submit: New GeneRIF Correction See all GeneRIFs (171)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association scan of dental caries in the permanent dentition. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

REN100675 (e-PCR)
- UniSTS:425472

REN100676 (e-PCR)
- UniSTS:425473

REN100677 (e-PCR)
- UniSTS:425474

REN100678 (e-PCR)
- UniSTS:425475

REN100679 (e-PCR)
- UniSTS:425476

REN100681 (e-PCR)
- UniSTS:425478

REN100683 (e-PCR)
- UniSTS:425480

REN100684 (e-PCR)
- UniSTS:425481

REN100686 (e-PCR)
- UniSTS:425483

REN100688 (e-PCR)
- UniSTS:425485

REN100689 (e-PCR)
- UniSTS:425486

REN100690 (e-PCR)
- UniSTS:425487

REN100691 (e-PCR)
- UniSTS:425488

REN100692 (e-PCR)
- UniSTS:425489

ECD01033 (e-PCR)
- UniSTS:282141

ECD00007 (e-PCR)
- UniSTS:281121

ECD11608 (e-PCR)
- UniSTS:292644

SHGC-33814 (e-PCR)
- UniSTS:76593

ECD10098 (e-PCR)
- UniSTS:291138

ECD00308 (e-PCR)
- UniSTS:281421

ECD01089 (e-PCR)
- UniSTS:282196

D7S2774 (e-PCR)
- UniSTS:51285

ECD00070 (e-PCR)
- UniSTS:281184

PMC140663P1 (e-PCR)
- UniSTS:270953

ECD00084 (e-PCR)
- UniSTS:281198

ECD00344 (e-PCR)
- UniSTS:281455

ECD00088 (e-PCR)
- UniSTS:281202

HOXA10_1370 (e-PCR)
- UniSTS:462252

ECD00416 (e-PCR)
- UniSTS:281527

RH80053 (e-PCR)
- UniSTS:83907

REN100641 (e-PCR)
- UniSTS:425438

REN100642 (e-PCR)
- UniSTS:425439

REN100643 (e-PCR)
- UniSTS:425440

REN100644 (e-PCR)
- UniSTS:425441

REN100645 (e-PCR)
- UniSTS:425442

REN100646 (e-PCR)
- UniSTS:425443

REN100647 (e-PCR)
- UniSTS:425444

REN100648 (e-PCR)
- UniSTS:425445

REN100649 (e-PCR)
- UniSTS:425446

REN100654 (e-PCR)
- UniSTS:425451

REN100655 (e-PCR)
- UniSTS:425452

REN100656 (e-PCR)
- UniSTS:425453

REN100657 (e-PCR)
- UniSTS:425454

REN100658 (e-PCR)
- UniSTS:425455

REN100659 (e-PCR)
- UniSTS:425456

REN100660 (e-PCR)
- UniSTS:425457

REN100661 (e-PCR)
- UniSTS:425458

REN100662 (e-PCR)
- UniSTS:425459

REN100663 (e-PCR)
- UniSTS:425460

REN100670 (e-PCR)
- UniSTS:425467

REN100671 (e-PCR)
- UniSTS:425468

REN100672 (e-PCR)
- UniSTS:425469

REN100673 (e-PCR)
- UniSTS:425470

REN100674 (e-PCR)
- UniSTS:425471

Readthrough HOXA10-HOXA9

Readthrough gene: HOXA10-HOXA9, Included gene: HOXA9

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
involved_in embryonic limb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in prostate gland development	IEA Inferred from Electronic Annotation more info
involved_in proximal/distal pattern formation	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in response to testosterone	IEA Inferred from Electronic Annotation more info
involved_in single fertilization	IEA Inferred from Electronic Annotation more info
involved_in skeletal system development	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in uterus development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Hox-A10

Names: homeo box A10; homeobox protein 1H; homeobox protein HOXA10; homeobox protein Hox-1.8; homeobox protein Hox-1H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018951.4 → NP_061824.3 homeobox protein Hox-A10

See identical proteins and their annotated locations for NP_061824.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.

Source sequence(s)

BC013971, BF196481, BX439708

Consensus CDS

CCDS5410.2

UniProtKB/Swiss-Prot

O43370, O43605, P31260, Q15949, Q504T1

Related

ENSP00000283921.4, ENST00000283921.5

Conserved Domains (1) summary

pfam00046
Location:339 → 392

Homeobox; Homeobox domain

RNA

NR_037939.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

BC013971, BC071843, BF196481, DB267919

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

27170605..27179861 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

27306614..27315870 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_153715.3: Suppressed sequence

Description

NM_153715.3: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.