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Dennd5b DENN domain containing 5B [ Mus musculus (house mouse) ]

Gene ID: 320560, updated on 2-Nov-2024

Summary

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Official Symbol
Dennd5bprovided by MGI
Official Full Name
DENN domain containing 5Bprovided by MGI
Primary source
MGI:MGI:2444273
See related
Ensembl:ENSMUSG00000030313 AllianceGenome:MGI:2444273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm17524; 9330160C06Rik; D030011O10Rik
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in positive regulation of triglyceride transport. Predicted to be located in membrane. Orthologous to human DENND5B (DENN domain containing 5B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 4.7), cerebellum adult (RPKM 4.0) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Dennd5b in Genome Data Viewer
Location:
6 G3; 6 78.71 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (148889566..149003178, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (148988069..149101680, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene SIN3-HDAC complex associated factor Neighboring gene RIKEN cDNA 3010003L21 gene Neighboring gene STARR-positive B cell enhancer ABC_E4884 Neighboring gene STARR-seq mESC enhancer starr_17846 Neighboring gene predicted gene, 25539 Neighboring gene STARR-positive B cell enhancer mm9_chr6:148938132-148938433 Neighboring gene STARR-seq mESC enhancer starr_17851 Neighboring gene STARR-positive B cell enhancer ABC_E4885 Neighboring gene 60S ribosomal protein L27 pseudogene Neighboring gene predicted gene 15781 Neighboring gene STARR-seq mESC enhancer starr_17853 Neighboring gene predicted gene, 22578 Neighboring gene SEH1-like (S. cerevisiae pseudogene Neighboring gene predicted gene, 23462 Neighboring gene STARR-seq mESC enhancer starr_17854 Neighboring gene STARR-positive B cell enhancer ABC_E8834 Neighboring gene STARR-seq mESC enhancer starr_17857 Neighboring gene STARR-positive B cell enhancer mm9_chr6:149081472-149081773 Neighboring gene electron transfer flavoprotein beta subunit lysine methyltransferase Neighboring gene STARR-seq mESC enhancer starr_17859 Neighboring gene antagonist of mitotic exit network 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dennd5b-Deficient Mice are Resistant to PCSK9-Induced Hypercholesterolemia and Diet-Induced Hepatic Steatosis. Mobilia M, et al. J Lipid Res, 2022 Dec. PMID 36243100, Free PMC Article
  2. DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass. Gordon SM, et al. Sci Rep, 2019 Mar 5. PMID 30837651, Free PMC Article
  3. Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation. Iwaki A, et al. FASEB J, 2020 Jul. PMID 32496646
  4. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dennd5b-Deficient Mice are Resistant to PCSK9-Induced Hypercholesterolemia and Diet-Induced Hepatic Steatosis.
    Title: Dennd5b-Deficient Mice are Resistant to PCSK9-Induced Hypercholesterolemia and Diet-Induced Hepatic Steatosis.
  2. DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass.
    Title: DENND5B Regulates Intestinal Triglyceride Absorption and Body Mass.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of triglyceride transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DENN domain-containing protein 5B
Names
DENN/MADD domain containing 5B
RAB6IP1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177192.3 → NP_796166.2  DENN domain-containing protein 5B

    See identical proteins and their annotated locations for NP_796166.2

    Status: VALIDATED

    Source sequence(s)
    AC140327, AK135015, BB656426, BC132535, CN537548, CV558497
    Consensus CDS
    CCDS20714.2
    UniProtKB/Swiss-Prot
    A2RSQ0, Q8BII7, Q8BWK2
    Related
    ENSMUSP00000107182.2, ENSMUST00000111557.8
    Conserved Domains (6) summary
    smart00801
    Location:499 → 574
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:19 → 120
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:936 → 1044
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02141
    Location:187 → 375
    DENN; DENN (AEX-3) domain
    pfam02759
    Location:780 → 924
    RUN; RUN domain
    cl02689
    Location:1127 → 1264
    RUN; RUN domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    148889566..149003178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507063.5 → XP_006507126.1  DENN domain-containing protein 5B isoform X1

    Conserved Domains (6) summary
    smart00801
    Location:521 → 596
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:19 → 142
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:958 → 1066
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02141
    Location:209 → 397
    DENN; DENN (AEX-3) domain
    pfam02759
    Location:802 → 946
    RUN; RUN domain
    cl02689
    Location:1149 → 1286
    RUN; RUN domain

  2. XM_017321643.2 → XP_017177132.1  DENN domain-containing protein 5B isoform X2

    Conserved Domains (6) summary
    smart00801
    Location:421 → 496
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    smart00800
    Location:1 → 42
    uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:858 → 966
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02141
    Location:109 → 297
    DENN; DENN (AEX-3) domain
    pfam02759
    Location:702 → 846
    RUN; RUN domain
    cl02689
    Location:1049 → 1186
    RUN; RUN domain

  3. XM_036166229.1 → XP_036022122.1  DENN domain-containing protein 5B isoform X3

    Conserved Domains (5) summary
    smart00801
    Location:193 → 268
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:630 → 738
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02759
    Location:474 → 618
    RUN; RUN domain
    cl02689
    Location:821 → 958
    RUN; RUN domain
    cl11519
    Location:1 → 69
    DENN; DENN (AEX-3) domain

  4. XM_030255459.2 → XP_030111319.1  DENN domain-containing protein 5B isoform X3

    Conserved Domains (5) summary
    smart00801
    Location:193 → 268
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:630 → 738
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02759
    Location:474 → 618
    RUN; RUN domain
    cl02689
    Location:821 → 958
    RUN; RUN domain
    cl11519
    Location:1 → 69
    DENN; DENN (AEX-3) domain

  5. XM_036166230.1 → XP_036022123.1  DENN domain-containing protein 5B isoform X4

    Conserved Domains (4) summary
    smart00801
    Location:77 → 152
    dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
    cd01757
    Location:514 → 622
    PLAT_RAB6IP1; PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed ...
    pfam02759
    Location:358 → 502
    RUN; RUN domain
    cl02689
    Location:705 → 842
    RUN; RUN domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RSQ0.2 GenPept UniProtKB/Swiss-Prot:A2RSQ0

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