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Vwc2l von Willebrand factor C domain-containing protein 2-like [ Mus musculus (house mouse) ]

Gene ID: 320460, updated on 18-Sep-2024

Summary

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Official Symbol
Vwc2lprovided by MGI
Official Full Name
von Willebrand factor C domain-containing protein 2-likeprovided by MGI
Primary source
MGI:MGI:2444069
See related
Ensembl:ENSMUSG00000045648 AllianceGenome:MGI:2444069
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Brl; A830006F12Rik
Summary
Acts upstream of or within negative regulation of BMP signaling pathway and positive regulation of neuron differentiation. Located in extracellular space. Part of AMPA glutamate receptor complex. Is expressed in brain; central nervous system; hippocampus; hypothalamus; and thalamus. Orthologous to human VWC2L (von Willebrand factor C domain containing 2 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Vwc2l in Genome Data Viewer
Location:
1 C3; 1 35.46 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (70764471..70928097)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (70725439..70888938)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 16 Neighboring gene STARR-seq mESC enhancer starr_01229 Neighboring gene predicted gene, 23422 Neighboring gene predicted gene, 57571 Neighboring gene STARR-seq mESC enhancer starr_01230 Neighboring gene predicted gene, 29906 Neighboring gene predicted gene, 57799 Neighboring gene STARR-positive B cell enhancer ABC_E5769 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01231 Neighboring gene predicted gene, 53490 Neighboring gene BRCA1 associated RING domain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Modulation of matrix mineralization by Vwc2-like protein and its novel splicing isoforms. Ohyama Y, et al. Biochem Biophys Res Commun, 2012 Feb 3. PMID 22209847, Free PMC Article
  2. A novel neural-specific BMP antagonist, Brorin-like, of the Chordin family. Miwa H, et al. FEBS Lett, 2009 Nov 19. PMID 19852960
  3. Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons. Machado CB, et al. Development, 2014 Feb. PMID 24496616, Free PMC Article
  4. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Schwenk J, et al. Neuron, 2012 May 24. PMID 22632720
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AMPA glutamate receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
von Willebrand factor C domain-containing protein 2-like
Names
Brorin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310658.2 → NP_001297587.1  von Willebrand factor C domain-containing protein 2-like isoform 2 precursor

    See identical proteins and their annotated locations for NP_001297587.1

    Status: VALIDATED

    Source sequence(s)
    AC129933, AC130481
    Consensus CDS
    CCDS78606.1
    UniProtKB/Swiss-Prot
    Q505H4
    Related
    ENSMUSP00000125014.2, ENSMUST00000161937.2

  2. NM_177164.4 → NP_796138.2  von Willebrand factor C domain-containing protein 2-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_796138.2

    Status: VALIDATED

    Source sequence(s)
    AC129933, AC130481
    Consensus CDS
    CCDS15028.1
    UniProtKB/Swiss-Prot
    B7X8X0, E0CXU0, E6Y2G9, Q505H4, Q8BNE9, Q8BNU5
    Related
    ENSMUSP00000058142.6, ENSMUST00000053922.12
    Conserved Domains (1) summary
    cl17735
    Location:116 → 171
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    70764471..70928097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496064.4 → XP_006496127.1  von Willebrand factor C domain-containing protein 2-like isoform X2

    Conserved Domains (1) summary
    cl17735
    Location:116 → 171
    VWC; von Willebrand factor type C domain

  2. XM_006496063.5 → XP_006496126.1  von Willebrand factor C domain-containing protein 2-like isoform X1

    See identical proteins and their annotated locations for XP_006496126.1

    UniProtKB/Swiss-Prot
    B7X8X0, E0CXU0, E6Y2G9, Q505H4, Q8BNE9, Q8BNU5
    Conserved Domains (1) summary
    cl17735
    Location:116 → 171
    VWC; von Willebrand factor type C domain

RNA

  1. XR_373257.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q505H4.1 GenPept UniProtKB/Swiss-Prot:Q505H4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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