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Cadps2 Ca2+-dependent activator protein for secretion 2 [ Mus musculus (house mouse) ]

Gene ID: 320405, updated on 2-Nov-2024

Summary

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Official Symbol
Cadps2provided by MGI
Official Full Name
Ca2+-dependent activator protein for secretion 2provided by MGI
Primary source
MGI:MGI:2443963
See related
Ensembl:ENSMUSG00000017978 AllianceGenome:MGI:2443963
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cpd2; Caps2; Caps-2; A230044C21Rik
Summary
Predicted to enable lipid binding activity and metal ion binding activity. Involved in synaptic vesicle priming. Acts upstream of or within cellular response to starvation; hematopoietic stem cell homeostasis; and positive regulation of exocytosis. Located in cytoplasmic vesicle; postsynaptic membrane; and presynaptic membrane. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynapse. Is expressed in several structures, including brain; genitourinary system; sensory organ; skeleton; and spinal cord. Used to study autism spectrum disorder. Orthologous to human CADPS2 (calcium dependent secretion activator 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 18.3), cortex adult (RPKM 6.9) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Cadps2 in Genome Data Viewer
Location:
6 A3.1; 6 10.57 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (23262765..23840662, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (23262773..23841175, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA C130093G08 gene Neighboring gene STARR-seq mESC enhancer starr_15332 Neighboring gene Fez family zinc finger 1 Neighboring gene STARR-seq mESC enhancer starr_15334 Neighboring gene STARR-seq mESC enhancer starr_15336 Neighboring gene STARR-seq mESC enhancer starr_15337 Neighboring gene predicted gene, 38775 Neighboring gene STARR-seq mESC enhancer starr_15338 Neighboring gene ring finger protein 133 Neighboring gene ring finger protein 148 Neighboring gene cell division cycle 20 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_15339 Neighboring gene STARR-seq mESC enhancer starr_15340 Neighboring gene STARR-seq mESC enhancer starr_15342 Neighboring gene taste receptor, type 2, member 118 Neighboring gene STARR-seq mESC enhancer starr_15345 Neighboring gene STARR-seq mESC enhancer starr_15346 Neighboring gene solute carrier family 13 (sodium/sulfate symporters), member 1 Neighboring gene predicted gene 20706

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Calcium-dependent activator protein for secretion 2 (CADPS2) deficiency causes abnormal synapse development in hippocampal mossy fiber terminals. Shinoda Y, et al. Neurosci Lett, 2018 Jun 11. PMID 29689341
  2. Impaired cerebellar development and function in mice lacking CAPS2, a protein involved in neurotrophin release. Sadakata T, et al. J Neurosci, 2007 Mar 7. PMID 17344385, Free PMC Article
  3. Tissue distribution of Ca2+-dependent activator protein for secretion family members CAPS1 and CAPS2 in mice. Sadakata T, et al. J Histochem Cytochem, 2007 Mar. PMID 17164411
  4. Alternative splicing variations in mouse CAPS2: differential expression and functional properties of splicing variants. Sadakata T, et al. BMC Neurosci, 2007 Apr 12. PMID 17428348, Free PMC Article
  5. Analysis of gene expression in Ca(2+)-dependent activator protein for secretion 2 (Cadps2) knockout cerebellum using GeneChip and KEGG pathways. Sadakata T, et al. Neurosci Lett, 2017 Feb 3. PMID 28041965

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior.
    Title: Down-regulation of habenular calcium-dependent secretion activator 2 induces despair-like behavior.
  2. CAPS2 deficiency induces proopiomelanocortin accumulation in pituitary and affects food intake behavior in mice.
    Title: CAPS2 deficiency induces proopiomelanocortin accumulation in pituitary and affects food intake behavior in mice.
  3. The data suggest that CADPS2-mediated secretion of BDNF/NT-3 may be involved in development and maturation of synapses and in the balance between inhibitory and excitatory synapses.
    Title: Aspects of excitatory/inhibitory synapses in multiple brain regions are correlated with levels of brain-derived neurotrophic factor/neurotrophin-3.
  4. Study looked at synaptic microstructures of hippocampal mossy fiber (MF) terminals in Calcium-dependent activator protein for secretion 2 (Cadps2) knockout mice. Findings suggest that CADPS2 plays a critical role in MF synaptic development and functional organization.
    Title: Calcium-dependent activator protein for secretion 2 (CADPS2) deficiency causes abnormal synapse development in hippocampal mossy fiber terminals.
  5. results suggest that deregulated gene expression caused by loss of Cadps2 may cause developmental deficits and/or pathological symptoms, resulting in autistic-like phenotypes
    Title: Analysis of gene expression in Ca(2+)-dependent activator protein for secretion 2 (Cadps2) knockout cerebellum using GeneChip and KEGG pathways.
  6. CAPS2 plays an important role in subcellular locality (axonal vs. somato-dendritic) of enhanced BDNF and NT-3 release, which is indispensable for proper development of postnatal cerebellum.
    Title: Axonal localization of Ca2+-dependent activator protein for secretion 2 is critical for subcellular locality of brain-derived neurotrophic factor and neurotrophin-3 release affecting proper development of postnatal mouse cerebellum.
  7. Data suggest that adequate levels of CAPS2 are critical for normal brain development and normal behavior; allelic changes due to copy number variation may contribute to autistic behavior.
    Title: Autistic-like behavioral phenotypes in a mouse model with copy number variation of the CAPS2/CADPS2 gene.
  8. Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice
    Title: Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice.
  9. results suggest that CAPS2 mediates the depolarization-dependent release of NT-3 and BDNF from granule cells, leading to regulation in cell differentiation and survival during cerebellar development
    Title: The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival.
  10. identification, cloning, and comparative characterization of a second mammalian CAPS isoform, CAPS2; concluded that at the functional level, CAPS2 is largely redundant with CAPS1
    Title: A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in dense core granule exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle priming IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within synaptic vesicle priming IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in synaptic vesicle priming IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in parallel fiber to Purkinje cell synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcium-dependent secretion activator 2
Names
cerebellum postnatal development associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252105.2 → NP_001239034.1  calcium-dependent secretion activator 2 isoform 2

    See identical proteins and their annotated locations for NP_001239034.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (2, also known as CAPS2a) that is shorter than isoform 1.
    Source sequence(s)
    AC153636, AC153639, AC153831, AC155850, AC167725
    Consensus CDS
    CCDS57412.1
    UniProtKB/TrEMBL
    E9Q835
    Related
    ENSMUSP00000111015.3, ENSMUST00000115358.9
    Conserved Domains (4) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:493 → 592
    PH; PH domain
    pfam06292
    Location:802 → 902
    DUF1041; Domain of Unknown Function (DUF1041)

  2. NM_001252106.2 → NP_001239035.1  calcium-dependent secretion activator 2 isoform 3

    See identical proteins and their annotated locations for NP_001239035.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, but includes an additional in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (3, also known as CAPS2c) is shorter than isoform 1.
    Source sequence(s)
    AC153636, AC153639, AC153831, AC155850, AC167725
    UniProtKB/TrEMBL
    A4PI82, E9Q835
    Conserved Domains (4) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 611
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:493 → 558
    PH; PH domain
    pfam06292
    Location:735 → 835
    DUF1041; Domain of Unknown Function (DUF1041)

  3. NM_001252107.2 → NP_001239036.1  calcium-dependent secretion activator 2 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks several exons in the central and 3' coding regions, but includes an alternate 3' exon and thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4, also known as CAPS2d) has a distinct and significantly shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC153636, AC153831, AC155850, AC167725
    Consensus CDS
    CCDS57413.1
    UniProtKB/TrEMBL
    A4PI83
    Related
    ENSMUSP00000111013.3, ENSMUST00000115356.3
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:493 → 592
    PH; PH domain

  4. NM_001252108.2 → NP_001239037.1  calcium-dependent secretion activator 2 isoform 5

    See identical proteins and their annotated locations for NP_001239037.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks several exons in the central and 3' coding regions, but includes an alternate 3' exon and thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5, also known as CAPS2e) has a distinct and significantly shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC153636, AC153831, AC155850, AC167725
    UniProtKB/TrEMBL
    A4PI83, A4PI84
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:493 → 592
    PH; PH domain

  5. NM_001252109.1 → NP_001239038.1  calcium-dependent secretion activator 2 isoform 6

    See identical proteins and their annotated locations for NP_001239038.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks several exons in the central and 3' coding regions, but includes an alternate 3' exon and thus differs in its 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (6, also known as CAPS2f) has a distinct and significantly shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AB291946, AC153636
    UniProtKB/TrEMBL
    A4PI80

  6. NM_001252110.2 → NP_001239039.1  calcium-dependent secretion activator 2 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks three in-frame exons in the central coding region, but includes an additional in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (7) is shorter than isoform 1.
    Source sequence(s)
    AC153636, AC153639, AC153831, AC155850, AC167725
    Consensus CDS
    CCDS57411.1
    UniProtKB/TrEMBL
    A0A0M3HEP6
    Related
    ENSMUSP00000111018.3, ENSMUST00000115361.9
    Conserved Domains (4) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:493 → 592
    PH; PH domain
    pfam06292
    Location:802 → 892
    DUF1041; Domain of Unknown Function (DUF1041)

  7. NM_001403608.1 → NP_001390537.1  calcium-dependent secretion activator 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC153636, AC153639, AC153831, AC155850, AC167725

  8. NM_001403630.1 → NP_001390559.1  calcium-dependent secretion activator 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC153636, AC153639, AC153831, AC155850, AC167725
    UniProtKB/Swiss-Prot
    O08903, Q66JM7, Q6PCL7, Q76I88, Q7TMM6, Q80ZV8, Q8BL25, Q8BY04, Q8BYR5, Q8K3K6
    Related
    ENSMUSP00000064876.9, ENSMUST00000069074.14

  9. NM_153163.5 → NP_694803.3  calcium-dependent secretion activator 2 isoform 1

    See identical proteins and their annotated locations for NP_694803.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as CAPS2b).
    Source sequence(s)
    AC153636, AC153639, AC153831, AC155850, AC167725
    Consensus CDS
    CCDS39439.1
    UniProtKB/TrEMBL
    A4PI81, E9Q835
    Related
    ENSMUSP00000018122.8, ENSMUST00000018122.14
    Conserved Domains (4) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam00169
    Location:493 → 592
    PH; PH domain
    pfam06292
    Location:802 → 902
    DUF1041; Domain of Unknown Function (DUF1041)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    23262765..23840662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036166226.1 → XP_036022119.1  calcium-dependent secretion activator 2 isoform X7

    UniProtKB/TrEMBL
    A0A0M3HEP6
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 892
    DUF1041; Domain of Unknown Function (DUF1041)

  2. XM_006505111.3 → XP_006505174.1  calcium-dependent secretion activator 2 isoform X5

    UniProtKB/TrEMBL
    A0A0M3HEP6
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 890
    DUF1041; Domain of Unknown Function (DUF1041)

  3. XM_030255457.2 → XP_030111317.1  calcium-dependent secretion activator 2 isoform X13

    UniProtKB/TrEMBL
    A0A0M3HEP6
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 893
    DUF1041; Domain of Unknown Function (DUF1041)

  4. XM_006505109.3 → XP_006505172.1  calcium-dependent secretion activator 2 isoform X3

    UniProtKB/TrEMBL
    A0A0M3HEP6
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 893
    DUF1041; Domain of Unknown Function (DUF1041)

  5. XM_006505115.3 → XP_006505178.1  calcium-dependent secretion activator 2 isoform X12

    UniProtKB/TrEMBL
    E9Q835
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 897
    DUF1041; Domain of Unknown Function (DUF1041)

  6. XM_036166228.1 → XP_036022121.1  calcium-dependent secretion activator 2 isoform X16

    UniProtKB/TrEMBL
    E9Q835
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 899
    DUF1041; Domain of Unknown Function (DUF1041)

  7. XM_036166227.1 → XP_036022120.1  calcium-dependent secretion activator 2 isoform X10

    UniProtKB/TrEMBL
    E9Q835
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 899
    DUF1041; Domain of Unknown Function (DUF1041)

  8. XM_006505110.3 → XP_006505173.1  calcium-dependent secretion activator 2 isoform X4

    See identical proteins and their annotated locations for XP_006505173.1

    UniProtKB/TrEMBL
    E9Q835
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 897
    DUF1041; Domain of Unknown Function (DUF1041)

  9. XM_006505108.3 → XP_006505171.1  calcium-dependent secretion activator 2 isoform X2

    UniProtKB/TrEMBL
    E9Q835
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 897
    DUF1041; Domain of Unknown Function (DUF1041)

  10. XM_006505113.3 → XP_006505176.1  calcium-dependent secretion activator 2 isoform X8

    UniProtKB/TrEMBL
    E9Q835
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 900
    DUF1041; Domain of Unknown Function (DUF1041)

  11. XM_017321641.3 → XP_017177130.1  calcium-dependent secretion activator 2 isoform X15

    UniProtKB/TrEMBL
    E9Q835
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 900
    DUF1041; Domain of Unknown Function (DUF1041)

  12. XM_017321640.3 → XP_017177129.1  calcium-dependent secretion activator 2 isoform X11

    UniProtKB/TrEMBL
    E9Q835
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 900
    DUF1041; Domain of Unknown Function (DUF1041)

  13. XM_006505107.3 → XP_006505170.1  calcium-dependent secretion activator 2 isoform X1

    UniProtKB/TrEMBL
    E9Q835
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 900
    DUF1041; Domain of Unknown Function (DUF1041)

  14. XM_006505114.4 → XP_006505177.1  calcium-dependent secretion activator 2 isoform X9

    UniProtKB/TrEMBL
    E9Q835
    Conserved Domains (3) summary
    smart00239
    Location:369 → 452
    C2; Protein kinase C conserved region 2 (CalB)
    cd01234
    Location:485 → 604
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:802 → 900
    DUF1041; Domain of Unknown Function (DUF1041)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BYR5.2 GenPept UniProtKB/Swiss-Prot:Q8BYR5

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