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Bcorl1 BCL6 co-repressor-like 1 [ Mus musculus (house mouse) ]

Gene ID: 320376, updated on 2-Nov-2024

Summary

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Official Symbol
Bcorl1provided by MGI
Official Full Name
BCL6 co-repressor-like 1provided by MGI
Primary source
MGI:MGI:2443910
See related
Ensembl:ENSMUSG00000036959 AllianceGenome:MGI:2443910
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6720425J07Rik; B930011H20Rik
Summary
Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Is expressed in brain. Human ortholog(s) of this gene implicated in Shukla-Vernon syndrome. Orthologous to human BCORL1 (BCL6 corepressor like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 2.4), CNS E11.5 (RPKM 2.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Bcorl1 in Genome Data Viewer
Location:
X A5; X 25.64 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (47430235..47496945)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (48341358..48408068)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7688 Neighboring gene predicted gene, 39511 Neighboring gene RIKEN cDNA 9530027J09 gene Neighboring gene UTP14A small subunit processome component Neighboring gene STARR-positive B cell enhancer mm9_chrX:45637714-45638015 Neighboring gene STARR-seq mESC enhancer starr_47113 Neighboring gene STARR-seq mESC enhancer starr_47114 Neighboring gene STARR-seq mESC enhancer starr_47116 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45782874-45783027 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:45786781-45786934 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene apoptosis-inducing factor, mitochondrion-associated 1 Neighboring gene STARR-seq mESC enhancer starr_47122

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human X chromosome exome sequencing identifies BCORL1 as contributor to spermatogenesis. Lu C, et al. J Med Genet, 2021 Jan. PMID 32376790
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
BCL-6 corepressor-like protein 1
Names
BCoR-L1
BCoR-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178782.4 → NP_848897.3  BCL-6 corepressor-like protein 1

    See identical proteins and their annotated locations for NP_848897.3

    Status: VALIDATED

    Source sequence(s)
    AK081004, AL844594, CJ176997, CO044036
    Consensus CDS
    CCDS40961.1
    UniProtKB/Swiss-Prot
    A2AQH4, Q8BMH7, Q8BV26, Q8BW58
    UniProtKB/TrEMBL
    F8WJL9
    Related
    ENSMUSP00000122000.2, ENSMUST00000136348.8
    Conserved Domains (5) summary
    PHA03247
    Location:182 → 630
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1662 → 1775
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    pfam05109
    Location:442 → 833
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1494 → 1525
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1498 → 1589
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    47430235..47496945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161982.1 → XP_036017875.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AQH4, Q8BMH7, Q8BV26, Q8BW58
    UniProtKB/TrEMBL
    F8WJL9
    Conserved Domains (5) summary
    PHA03247
    Location:182 → 630
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1662 → 1775
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    pfam05109
    Location:442 → 833
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1494 → 1525
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1498 → 1589
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006541497.4 → XP_006541560.1  BCL-6 corepressor-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006541560.1

    UniProtKB/Swiss-Prot
    A2AQH4, Q8BMH7, Q8BV26, Q8BW58
    UniProtKB/TrEMBL
    F8WJL9
    Conserved Domains (5) summary
    PHA03247
    Location:182 → 630
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1662 → 1775
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    pfam05109
    Location:442 → 833
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1494 → 1525
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1498 → 1589
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_006541499.5 → XP_006541562.1  BCL-6 corepressor-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006541562.1

    UniProtKB/Swiss-Prot
    A2AQH4, Q8BMH7, Q8BV26, Q8BW58
    UniProtKB/TrEMBL
    F8WJL9
    Conserved Domains (5) summary
    PHA03247
    Location:182 → 630
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1662 → 1775
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    pfam05109
    Location:442 → 833
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1494 → 1525
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1498 → 1589
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_006541498.5 → XP_006541561.1  BCL-6 corepressor-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006541561.1

    UniProtKB/Swiss-Prot
    A2AQH4, Q8BMH7, Q8BV26, Q8BW58
    UniProtKB/TrEMBL
    F8WJL9
    Related
    ENSMUSP00000039898.7, ENSMUST00000037596.13
    Conserved Domains (5) summary
    PHA03247
    Location:182 → 630
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1662 → 1775
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    pfam05109
    Location:442 → 833
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1494 → 1525
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1498 → 1589
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_030251371.2 → XP_030107231.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AQH4, Q8BMH7, Q8BV26, Q8BW58
    UniProtKB/TrEMBL
    F8WJL9
    Conserved Domains (5) summary
    PHA03247
    Location:182 → 630
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1662 → 1775
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    pfam05109
    Location:442 → 833
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1494 → 1525
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1498 → 1589
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_006541500.4 → XP_006541563.1  BCL-6 corepressor-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006541563.1

    UniProtKB/Swiss-Prot
    A2AQH4, Q8BMH7, Q8BV26, Q8BW58
    UniProtKB/TrEMBL
    F8WJL9
    Conserved Domains (5) summary
    PHA03247
    Location:182 → 630
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1662 → 1775
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    pfam05109
    Location:442 → 833
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1494 → 1525
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1498 → 1589
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_030251370.1 → XP_030107230.1  BCL-6 corepressor-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AQH4, Q8BMH7, Q8BV26, Q8BW58
    UniProtKB/TrEMBL
    F8WJL9
    Conserved Domains (5) summary
    PHA03247
    Location:182 → 630
    PHA03247; large tegument protein UL36; Provisional
    cd14260
    Location:1662 → 1775
    PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
    pfam05109
    Location:442 → 833
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    sd00045
    Location:1494 → 1525
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:1498 → 1589
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AQH4.1 GenPept UniProtKB/Swiss-Prot:A2AQH4

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