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CG2145 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32027, updated on 2-Nov-2024

Summary

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Official Symbol
CG2145provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0030251
Locus tag
Dmel_CG2145
See related
AllianceGenome:FB:FBgn0030251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG2145; Dmel_CG2145
Summary
Enables RNA endonuclease activity. Involved in mRNA destabilization; negative regulation of lipid catabolic process; and post-transcriptional gene silencing. Is active in endoplasmic reticulum. Is expressed in adult head. Orthologous to human ENDOU (endonuclease, poly(U) specific). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG2145 in Genome Data Viewer
Location:
9F11-9F12; 1-33 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10927399..10929712)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10821432..10823745)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene vermilion Neighboring gene Myosin 10A Neighboring gene Rab at 9Fa Neighboring gene Rab at 9Fb

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration. Laneve P, et al. Sci Rep, 2017 Jan 31. PMID 28139767, Free PMC Article
  2. Proteomics of protein trafficking by in vivo tissue-specific labeling. Droujinine IA, et al. Nat Commun, 2021 Apr 22. PMID 33888706, Free PMC Article
  3. The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging. Sun X, et al. Nat Commun, 2023 Oct 6. PMID 37803019, Free PMC Article
  4. Silencing of Euchromatic Transposable Elements as a Consequence of Nuclear Lamina Dysfunction. Cavaliere V, et al. Cells, 2020 Mar 5. PMID 32151001, Free PMC Article
  5. Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase. Radyuk SN, et al. Mech Ageing Dev, 2012 Jun. PMID 22579812

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA endonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mRNA destabilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of lipid catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-transcriptional gene silencing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG2145-PA
CG2145-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    10927399..10929712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132440.2 → NP_572668.1  uncharacterized protein Dmel_CG2145, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572668.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9UNF0, Q8SY54, Q9VZ49
    UniProtKB/TrEMBL
    X2JJD6
    Related
    FBpp0073243, FBtr0073387
    Conserved Domains (1) summary
    pfam09412
    Location:330 → 590
    XendoU; Endoribonuclease XendoU

  2. NM_001298173.1 → NP_001285102.1  uncharacterized protein Dmel_CG2145, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285102.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A9UNF0, Q8SY54, Q9VZ49
    UniProtKB/TrEMBL
    X2JJD6
    Conserved Domains (1) summary
    pfam09412
    Location:330 → 590
    XendoU; Endoribonuclease XendoU
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZ49.1 Q9VZ49
X2JJD6 X2JJD6

Gene LinkOut

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